Monthly ART Injections Top Pills for HIV Patients With Adherence Problems
Long-acting cabotegravir/rilpivirine (Cabenuva; CAB/RPV-LA) appeared superior to daily oral antiretroviral therapy (ART) in maintaining viral load suppression for people living with HIV who have trouble adhering to oral ART, according to an interim analysis of a phase III trial. At 52 weeks, numerically fewer patients assigned to monthly injections of CAB/RPV-LA experienced regimen failure — […]
Novel Antibiotic Combo Bests Meropenem for Complicated UTIs
Cefepime-taniborbactam, an investigational beta-lactam and beta-lactamase inhibitor combination, was superior to meropenem for the treatment of hospitalized patients with complicated urinary tract infection (UTI), including acute pyelonephritis, a phase III randomized study showed. In the microbiologic intention-to-treat (ITT) population, the composite microbiologic and clinical success rate with the combination at test-of-cure (trial days 19 to […]
RET Inhibitor Posts Frontline Wins in Medullary Thyroid Cancer, NSCLC
MADRID — First-line treatment with the RET inhibitor selpercatinib (Retevmo) achieved superior outcomes in both medullary thyroid cancer (MTC) and advanced non-small cell lung cancer (NSCLC), according to results from two phase III trials presented here. In the LIBRETTO-531 trial, selpercatinib resulted in superior progression-free survival (PFS) and treatment failure-free survival (TFFS) compared with the […]
Opinion | Is Diabetes Bad for the Environment?
“The superior doctor prevents sickness. The mediocre doctor attends to impending sickness. The inferior doctor treats actual sickness.” – Chinese Proverb The management of diabetes today requires an understanding of the concept of the circular economy in eliminating waste and pollution, circulating products and materials at their highest level, and regenerating nature. Today, we saw […]
New Evidence Sheds Light on Stem Cell Transplantation for Progressive MS
Autologous hematopoietic stem cell transplantation (AHSCT) was not superior in preventing relapses or reducing disability progression than natalizumab (Tysabri) in progressive multiple sclerosis (MS), new research suggested. Patients with progressive MS, advanced disability, and low pre-treatment relapse activity who had AHSCT experienced similar on-treatment frequency of relapses as matched patients treated with natalizumab over up […]
Resistance exercise may be superior to aerobic exercise for getting better ZZZs
Resistance exercise may be superior to aerobic exercise as a way to get better sleep, and sleep is important for cardiovascular health, according to preliminary research to be presented at the American Heart Association’s Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Conference 2022. The meeting will be held in-person in Chicago and virtually Tuesday, March 1 […]
Long-Acting Injectable for HIV Prevention Passes Hurdles, but Barriers Remain
Long-acting injectable HIV prevention with cabotegravir was superior to daily oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine (TDF/FTC; Truvada) in men who have sex with men (MSM) and transgender women, a randomized trial found. Among more than 4,500 participants in the phase IIb/III trial, 13 incident infections occurred in the cabotegravir group compared with […]