Suicide Risk 8-Fold Higher After Common Reproductive Disorder Diagnosis
Suicidality was substantially higher among women diagnosed with polycystic ovary syndrome (PCOS), according to a Taiwanese population-based cohort study. PCOS-diagnosed patients had an 8.47-fold (95% CI 7.54-9.51) higher risk of attempted suicide compared with women without PCOS, Mu-Hong Chen, MD, PhD, of Taipei Veterans General Hospital in Taiwan, and colleagues found. Incidence of suicide attempts […]
Two-Stage Screening Strategy for Ovarian Cancer Continues to Show Progress
A two-stage ovarian cancer screening strategy substantially improved early-stage detection among average-risk postmenopausal women, according to long-term follow-up from a large prospective study. Combining serial CA125 values and conditional referral for transvaginal sonography (TVS) led to a sensitivity of 74% for detection of ovarian and borderline cancers. Cancers detected by the Risk of Ovarian Cancer […]
Maintenance Selinexor May Boost PFS in TP53 Wild-Type Advanced Endometrial Cancer
SEOUL, South Korea — Maintenance therapy with selinexor (Xpovio) seemed to substantially extend progression-free survival (PFS) in patients with wild-type TP53 advanced or recurrent endometrial cancer, according to data from the SIENDO trial. The updated, long-term data from the phase III study showed that, at a median follow-up of 25.3 months, median PFS was 27.4 […]
Stroke Data Hint at High Practice Variability Between EMS Agencies
Individual EMS agencies have varied substantially in their stroke case documentation, raising the question of whether problems might also extend to their operations and implementation of stroke protocols, according to preliminary work from Michigan. Based on 147 EMS agencies working in the state, their compliance with documenting time since last known well (LKW) for stroke […]
RT After Breast-Conserving Surgery Shows No Survival Advantage Decades Later
Radiotherapy after breast-conserving surgery for early breast cancer substantially reduced the risk of disease recurrence, yet the benefit did not translate to an improvement in overall survival (OS) at 30 years, a long-term analysis of the Scottish breast conservation trial showed. Compared with no radiotherapy, adjuvant locoregional radiotherapy reduced the risk of ipsilateral breast tumor […]
HPV Immunization Program Slashed New Cervical Cancer Cases
The introduction of a human papillomavirus (HPV) immunization program in England substantially reduced cases of cervical cancer and incidence of grade 3 cervical intraepithelial neoplasia (CIN3) in young women, particularly those who received the vaccine at the age of 12 or 13, researchers found. In their register-based population study, estimated relative reductions in cervical cancer […]
Just How Many New Depression, Anxiety Cases Popped Up in 2020?
Depressive and anxiety disorders increased substantially around the world since the start of the pandemic, hitting some groups harder than others, according to a new systematic review and meta-analyses. Two proxy measures for the impact of COVID-19 — daily infection rates and reductions in human mobility — were both significantly associated with surges in major […]
Ablation, CRT Boost Survival in Permanent Afib With Narrow QRS
A “pace-and-ablate” strategy substantially boosted survival for permanent atrial fibrillation (Afib) patients with a narrow QRS across the range of left ventricular ejection fraction (LVEF), the APAF-CRT trial showed. While relatively small with 133 patients after being stopped early for efficacy at a median 29 months of follow-up, the trial showed a relative 74% survival […]