Most People With TB Report No Persistent Cough
A significant proportion of people in the community with pulmonary tuberculosis (TB) have subclinical disease, according to a meta-analysis involving survey studies across Africa and Asia. In adjusted analyses, 82.8% (95% CI 78.6-86.6) of participants with TB reported no persistent cough and 62.5% (95% CI 56.6-68.7) reported no cough at all, according to Frank Cobelens, […]
Proteins Predict Signs of Alzheimer’s Disease
Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed. Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic […]
DOAC Cuts Stroke Risk From Subclinical Afib
PHILADELPHIA — For patients with subclinical atrial fibrillation (Afib, AF) detected by their pacemaker or defibrillator, direct oral anticoagulation brought their already low stroke risk even lower — but at a cost in bleeding events, the ARTESiA trial showed. Apixaban (Eliquis) treatment cut risk of stroke or systemic embolism 37% compared with low-dose aspirin over […]
Subclinical CVD Detected in Kids With Higher Arsenic Burden
Greater arsenic exposure was linked to children harboring subclinical cardiovascular disease (CVD) as early as age 9, based on data from Syracuse, New York. In this upstate community with a history of industrial waste, total arsenic level significantly correlated with carotid intima media thickness and concentric hypertrophy (the latter indicated by greater left ventricular mass […]
Earlier Detection of Cardiac Dysfunction Possible for Young Adult Cancer Survivors
Subclinical diastolic dysfunction may be detected among adult survivors of childhood cancer before left ventricular ejection fraction (LVEF) becomes abnormally low, according to longitudinal echocardiographic data. Among participants in the St. Jude Lifetime Cohort Study (SJLIFE) diagnosed with cancer at a median age of 8 years, the proportion of diastolic dysfunction was approximately 15% when […]