Novel Combination Active in Large B-Cell Lymphoma, Even After CAR-T
A phase Ib/II study demonstrated that mosunetuzumab (Lunsumio) plus polatuzumab vedotin (Polivy) induced durable responses in patients with relapsed or refractory large B-cell lymphoma (LBCL), including patients who relapsed after CAR T-cell therapy. The findings were presented at the recent American Society of Hematology (ASH) annual meeting and simultaneously published in Nature Medicine. In this […]
New reasons eating less fat should be one of your resolutions
A UC Riverside study to motivate your new year’s resolutions: it demonstrates that high-fat diets affect genes linked not only to obesity, colon cancer and irritable bowels, but also to the immune system, brain function, and potentially COVID-19 risk. While other studies have examined the effects of a high-fat diet, this one is unusual in […]
Financial Toxicity Among Single Mothers With Metastatic Breast Cancer
A study presented at the San Antonio Breast Cancer Symposium highlighted financial toxicity in underserved/underrepresented single mothers living with metastatic breast cancer, and how the situation can affect their physical, mental, and emotional health. In this exclusive MedPage Today video, Maryam Lustberg, MD, director of the Center for Breast Cancer at the Yale School of […]
Lower Blenrep Dose More Feasible With Revlimid in Myeloma, Early Trial Suggests
A dose-finding study presented at the recent American Society of Hematology annual meeting showed deep and durable responses with belantamab mafodotin (Blenrep) plus lenalidomide (Revlimid) and dexamethasone in relapsed or refractory multiple myeloma, with lower dosing of the B-cell maturation antigen (BCMA) proving more tolerable and feasible. In this MedPage Today video, Rakesh Popat, BSc, […]
You Think the TREE Is Crooked: Penile Fractures Up at Christmas
Talk about taking a break for the holidays: A new German study found that penile fractures are more likely to occur around Christmas Day. From 2005 to 2021, 3,421 men in Germany required a hospital stay for penile fractures, with 1.2% occurring from December 24-26 in each year, reported Nikolaos Pyrgidis, MD, MSc, of University […]
People Drop the Ball When It Comes to Safe Sex on New Year’s Eve
A new study in the annual BMJ Christmas issue suggests high levels of unprotected sex during New Year’s Eve celebrations in the U.S., with an increase in sales of levonorgestrel (Plan B) in the week after that surpasses other holidays. In this video interview, study author Brandon Wagner, PhD, of Texas Tech University in Lubbock, […]
Manipulation of gut microbiota with flaxseed could reduce breast cancer risk
A new study demonstrates that the human gut microbiome may be a factor in breast health. Lifestyle and diet have long been known to affect human health. In the study, flaxseed components called lignans were shown to influence the relationship between gut microorganisms and the expression of mammary gland microRNAs (miRNAs). A subset of these […]
Specific genetic variant may help prevent obesity
A preclinical study by Weill Cornell Medicine investigators shows that a specific human genetic variant of a receptor that stimulates insulin release may help individuals be more resistant to obesity. The researchers discovered that this variant behaves differently in the cell which may contribute to more efficient metabolism. The study, posted online in Molecular Metabolism […]
Antisense Drug Trial Provides Key Insights About Huntington’s Disease
The halted GENERATION HD1 (GENHD1) study of the investigational antisense drug tominersen provided insights about Huntington’s disease staging and informed future clinical trials, researchers said. The phase III study involved 791 manifest Huntington’s disease patients who received intrathecal tominersen 120 mg either every 8 weeks or every 16 weeks, or placebo. Based on an overall […]
Twin research indicates that that a vegan diet improves cardiovascular health
In a study with 22 pairs of identical twins, Stanford Medicine researchers and their colleagues have found that a vegan diet improves cardiovascular health in as little as eight weeks. Although it’s well-known that eating less meat improves cardiovascular health, diet studies are often hampered by factors such as genetic differences, upbringing and lifestyle choices. […]