Smoking during pregnancy may increase the risk of behavioral disorders in newborns, predicts AI
Although several studies have linked smoking during pregnancy with neurodevelopmental disorders, the results of behavioral experiments in mice prenatally exposed to nicotine have been inconsistent. In a recent study, scientists from Japan developed a deep learning-based framework to automatically observe and classify mice behavior in such experiments, producing more accurate and unbiased results. They show […]
Studies on coffee consumption: New biomarker proposed
In order to record coffee consumption in nutrition and health studies, researchers usually rely on self-reporting by participants. However, this is not always reliable. It would therefore be desirable to conduct additional studies to objectively verify individual consumption using biomarkers. A research team led by the Leibniz Institute for Food Systems Biology at the Technical […]
Liquid Biopsy Has Mixed Performance for Predicting Colon Cancer Outcomes
SAN FRANCISCO — In separate studies, liquid biopsy produced mixed results for guiding colon cancer treatment. Adjuvant chemotherapy guided by postoperative circulating tumor (ct) DNA did not lead to higher rates of DNA clearance as compared with patients who did not get chemotherapy. However, ctDNA did show promise for identifying patients with molecular residual disease […]
Year in Review: Follicular Lymphoma
Studies demonstrating high response rates and manageable safety profiles, along with FDA approvals, have supported bispecific antibodies as promising treatment options for follicular lymphoma. At the start of 2023, a new option became available with the accelerated approval of mosunetuzumab (Lunsumio) late last year. The first-in-class bispecific monoclonal antibody works by inducing CD20-directed CD3 T-cell […]
Sarepta’s Duchenne Gene Therapy Does Not Have ‘Unambiguous Evidence,’ FDA Staff Says
Clinical studies to date “do not provide unambiguous evidence” for SRP-9001 (delandistrogene moxeparvovec), an investigational gene therapy for ambulatory Duchenne muscular dystrophy patients, FDA reviewers said in briefing documents released ahead of an advisory committee meeting. The agency also raised safety concerns about the possibility of administering an ineffective gene therapy. Duchenne muscular dystrophy is […]
Time-restricted eating reshapes gene expression throughout the body: Salk researchers find that timing calorie intake synchronizes circadian rhythms across multiple systems in mice
Numerous studies have shown health benefits of time-restricted eating including increase in life span in laboratory studies, making practices like intermittent fasting a hot topic in the wellness industry. However, exactly how it affects the body on the molecular level, and how those changes interact across multiple organ systems, has not been well understood. Now, […]
New biomarkers for coffee consumption
In search of new biomarkers for nutrition and health studies, a research team from the Leibniz Institute for Food Systems Biology at the Technical University of Munich (LSB) has identified and structurally characterized three metabolites that could be considered as specific markers for individual coffee consumption. These are degradation products of a group of substances […]
Not Just a Miner’s Problem: Workplace Fumes, Dust Tied to RA
Adding to previous studies implicating on-the-job exposure to silica dust as a risk factor for rheumatoid arthritis (RA), new research now finds dozens of other occupational inhalants that also appear to contribute to RA development. Comparison of 4,033 cases of new-onset RA with 6,485 matched controls in Swedish registries indicated that exposure to any of […]
Popular dietary supplement causes cancer risk, brain metastasis, study finds
While previous studies have linked commercial dietary supplements like nicotinamide riboside (NR), a form of vitamin B3, to benefits related to cardiovascular, metabolic and neurological health, new research from the University of Missouri has found NR could actually increase the risk of serious disease, including developing cancer. The international team of researchers led by Elena […]
Pragmatic Trials May Help Increase Minority Participation in MS Research
Pragmatic trials may offer one way to increase minority populations in multiple sclerosis (MS) studies, investigators for the DELIVER-MS trial suggested. Race and ethnicity did not appear to influence decisions to participate in either the randomized or observational cohorts of the pragmatic DELIVER-MS study, or in treatment choices, reported Sarah Planchon, PhD, of the Cleveland […]