Intranasal Zavegepant Shows Promise in Acute Migraine
Zavegepant, an investigational nasal spray formulation of a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist, met its co-primary endpoints in a phase III randomized placebo-controlled trial of acute migraine. On both primary endpoints — 2-hour pain freedom (23.6% vs 14.9%, P<0.0001) and 2-hour freedom from most bothersome symptom (39.6% vs 31.1%, P=0.0012) — zavegepant was […]
New Insights Into Better Immunotherapy; Diabetes and Cancer; Skin Cancer Advice
In preclinical studies, a small-molecule activator of lymphocyte function-associated antigen 1 showed potential for transforming “cold” tumors into “hot” ones that are more responsive to immunotherapy. (University of Texas MD Anderson Cancer Center, Journal of Clinical Investigation) Helper T cells (CD4+) may have a bigger role in immune-system activity against cancer than previously recognized. (Washington […]