Novel Drug Cuts Proteinuria in APOL1-Mediated Kidney Disease
An investigative treatment targeting APOL1 activity significantly improved proteinuria APOL1-mediated kidney disease (AMKD), a proof-of-concept phase IIa study found. In a single-arm, open-label study, treatment with oral VX-147 — a small molecule acting as an APOL1 function inhibitor — significantly reduced urine protein to creatinine ratio (UPCR) by 47.6% (95% CI -60 to -31.3%) by […]
Study Confirms Declining Mammography Rates in Breast Cancer Survivors
Rates of follow-up mammography among breast cancer survivors declined significantly during the last decade, particularly among younger women, an analysis of health claims data showed. Rates of annual mammography decreased from 74.1% in 2004 to 67.1% in 2016, with all of the decline occurring from 2009 to 2016. Among breast cancer survivors ages 40 to […]
Another China-Developed PD-1 Inhibitor Makes Its Case in NSCLC
Adding the investigational PD-1 checkpoint inhibitor toripalimab to chemotherapy in first-line significantly improved progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without EGFR/ALK mutations, according to results from a study conducted in China. Median PFS improved from 5.6 months with chemotherapy alone to 8.4 months with the toripalimab-based combination (HR 0.49, 95% […]
Digital Device Proves Effective for Treating Urinary Incontinence in Women
Pelvic floor muscle training using a motion-based digital intravaginal device significantly improved symptoms for women with stress urinary incontinence (SUI) compared with a home training program, a virtually conducted randomized controlled trial showed. Participants who used the device had greater improvements in urinary symptom severity and degree of bother as measured by the Urogenital Distress […]
ADHD linked to hoarding behavior: As many as 1 in 5 adults with ADHD could have significant hoarding symptoms
New research has found that people with Attention Deficit/Hyperactivity Disorder (ADHD) are significantly more likely to also exhibit hoarding behaviours, which can have a serious impact on their quality of life. The study, published in the Journal of Psychiatric Research and funded by theBritish Academy and the Leverhulme Trust, found that almost one in five […]
Darolutamide Improves OS in Metastatic Prostate Cancer
Darolutamide (Nubeqa) combined with standard treatment significantly improved survival in patients with metastatic hormone-sensitive prostate cancer (mHSPC), the phase III ARASENS trial found. At data cutoff, patients who received darolutamide plus androgen deprivation therapy (ADT) and docetaxel had a 32.5% lower risk of death compared with the group who received placebo plus the standard (HR […]
Probiotics improve nausea and vomiting in pregnancy: Findings also provide clues to why some people experience more stomach upset during pregnancy
In a first-of-its-kind study, researchers at the UC Davis School of Medicine found that probiotics significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation. The findings were published in the journal Nutrients. Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy. “The cause of […]
Probiotics improve nausea and vomiting in pregnancy: Findings also provide clues to why some people experience more stomach upset during pregnancy
In a first-of-its-kind study, researchers at the UC Davis School of Medicine found that probiotics significantly improve the symptoms of pregnancy-related nausea, vomiting and constipation. The findings were published in the journal Nutrients. Nausea and vomiting affect about 85% of pregnancies and can significantly impact quality of life, particularly during early pregnancy. “The cause of […]
Iron Load in NAFLD Tied to Higher Liver Cancer Risk
Patients with nonalcoholic fatty liver disease (NAFLD) had a significantly higher risk of developing hepatocellular carcinoma (HCC) based on elevated biomarker levels of serum iron or transferrin saturation, a researcher reported. In an analysis of over 18,000 NAFLD patients, elevated serum iron levels over 175 μg/dL were associated with a more than two-fold higher risk […]
Doctors Warn Of Future Disease Outbreaks As Kids’ Vaccination Rates Drop
Routine vaccination rates for children have significantly dropped since the start of the coronavirus pandemic, leading doctors to worry that there could be outbreaks of vaccine-preventable diseases, including ones that carry more risk to children than COVID-19. The number of routine vaccines distributed through the Centers for Disease Control and Prevention’s Vaccines for Children program — which provides immunizations […]