Aldosterone Linked to Kidney Failure Risk, Irrespective of Diabetes
Higher serum aldosterone levels were linked to a greater risk of kidney failure in chronic kidney disease (CKD), both for those with and without diabetes, a study showed. Every doubling in aldosterone level was associated with 11% (95% CI 1.04-1.18) greater risk of progression of CKD to end-stage kidney disease or halving of estimated glomerular […]
Blood Biomarker Linked With Parkinson’s Disease
Serum neurofilament light (NfL), a measure of axonal injury, was associated with incident Parkinson’s disease, parkinsonian signs, and decline in physical functioning, a longitudinal study showed. Among 1,300 people in the Chicago Health and Aging Project (CHAP), a twofold higher concentration of serum NfL was associated with incident clinical Parkinson’s disease (OR 2.54, 95% CI […]
Check Troponin in RCC Patients Before Checkpoint-VEGFR Inhibitor Combo
Advanced renal cell carcinoma (RCC) patients with high serum levels of troponin T had a greater risk of serious cardiac events when treated with an immune checkpoint inhibitor and VEGFR inhibitor combination, data from the phase III JAVELIN Renal 101 trial indicated. For patients assigned to the avelumab (Bavencio) plus axitinib (Inlyta) arm, 17.1% of […]