RAF/MEK and FAK Inhibitor Combo Effective in Low-Grade Serous Ovarian Cancer
SEOUL, South Korea — The combination of avutometinib and defactinib achieved “exceptionally” high response rates in heavily pretreated patients with recurrent low-grade serous ovarian cancer (LGSOC), according to the ENGOT-ov60/GOG-3052/RAMP 201 trial. Moreover, responses were consistently high no matter how many previous lines of therapy patients received prior to study entry, reported Rachel N. Grisham […]
Maintenance Selinexor May Boost PFS in TP53 Wild-Type Advanced Endometrial Cancer
SEOUL, South Korea — Maintenance therapy with selinexor (Xpovio) seemed to substantially extend progression-free survival (PFS) in patients with wild-type TP53 advanced or recurrent endometrial cancer, according to data from the SIENDO trial. The updated, long-term data from the phase III study showed that, at a median follow-up of 25.3 months, median PFS was 27.4 […]
CDC Rats Out First U.S. Transmission of Seoul Hantavirus
Two service workers in Washington, D.C. contracted Seoul hantavirus in what is believed to be the first locally transmitted cases of the virus on U.S. soil. Both patients presented with several days of chills, high fever, headache, diarrhea, and vomiting. Both had acute kidney injury and responded to supportive treatment, and were later discharged. Rats […]