Supreme Court Appears Skeptical of Challenge to Abortion Pill Access
The Supreme Court seemed likely to preserve access to the widely used abortion pill mifepristone (Mifeprex), in the court’s first abortion case since it overturned Roe v. Wade 2 years ago. During oral arguments on Tuesday, justices appeared skeptical of the plaintiffs’ case for a lawsuit that questions whether the FDA overlooked safety concerns when […]
Maintenance Selinexor May Boost PFS in TP53 Wild-Type Advanced Endometrial Cancer
SEOUL, South Korea — Maintenance therapy with selinexor (Xpovio) seemed to substantially extend progression-free survival (PFS) in patients with wild-type TP53 advanced or recurrent endometrial cancer, according to data from the SIENDO trial. The updated, long-term data from the phase III study showed that, at a median follow-up of 25.3 months, median PFS was 27.4 […]
Good, and Safe, Results Tied to Oral Testosterone in Men With Deficiency
MIAMI — Oral testosterone replacement therapy (TRT) seemed safe and effective in men with testosterone deficiency, according to a meta-analysis. Among nine studies that looked at changes in serum total testosterone, only men with testosterone deficiency who took an oral agent — predominantly testosterone undecanoate — saw a significant increase in total testosterone, with a […]
Catheter-Directed Thrombolysis Promising for Intermediate-Risk Pulmonary Embolism
A modified reperfusion protocol for intermediate-risk pulmonary embolism (PE) seemed to work without causing excessive bleeding in the small randomized CANARY trial. Use of conventional catheter-directed thrombolysis (CDT) with alteplase led to 4.3% of patients showing right ventricular (RV) recovery at 3 months (in terms of echocardiographic RV/LV ratios >0.9), which was numerically, but not […]
Prediabetes May Be an Independent Risk Factor for MI
Even prediabetes seemed to spell bad news for heart health, according to a national inpatient sample study. Prediabetes — defined as an Hba1c between 5.7% to 6.4% — among hospitalized patients was associated with 41% higher odds for myocardial infarction (MI, OR 1.41, 95% CI 1.35-1.47) in a general model, reported Geethika Thota, MBBS, of […]
Menstrual Cycles Point to Link Between Sex Hormones and Long QT
SAN FRANCISCO — Cardiac repolarization dynamics seemed to cycle in sync with the menstrual cycle of some people with congenital and drug-induced long QT syndrome (LQTS), a small prospective study showed. Women with LQTS type 2 were found to have their QT interval — corrected with the Bazett formula (QTcB) and Fridericia’s method (QTcF) — […]
ADT Options for Prostate Cancer Come Out Even for Heart Safety
Androgen deprivation therapy (ADT) options for prostate cancer seemed to have a similar impact on the risk of cardiovascular events among people with documented heart disease, according to results from the PRONOUNCE trial, although the study was terminated early due to slow accrual. In 545 men, there was no statistically significant difference in the rate […]
Deadly Arrhythmias Less of a Risk for HF Patients on Dapagliflozin
An SGLT2 inhibitor seemed to offer protection from reduced ventricular arrhythmias in heart failure patients, according to a post hoc analysis of DAPA-HF. In that trial, the cohort randomized to dapagliflozin (Farxiga) had a reduced first occurrence of any ventricular arrhythmia, resuscitated cardiac arrest, or sudden death (5.9% vs 7.4% for placebo group; HR 0.79, […]