Rucaparib Gets a Win in Metastatic Castration-Resistant Prostate Cancer
SAN FRANCISCO — Imaging-based progression-free survival (PFS) was significantly longer with the PARP inhibitor rucaparib (Rubraca) compared with physician’s choice of therapy in patients with BRCA or ATM-associated metastatic castration-resistant prostate cancer (CRPC), the phase III TRITON3 study showed. All patients in the study had already progressed after treatment with a second-generation androgen receptor-pathway inhibitor […]
Rucaparib a Winner for PFS, But Not for OS, in Recurrent Ovarian Cancer
NEW YORK — Rucaparib (Rubraca) turned in mixed results for survival outcomes in patients with recurrent ovarian carcinoma, according to an ARIEL3 trial update. There was a benefit for progression-free survival (PFS), as treatment with the PARP inhibitor was tied to longer time-to-second disease progression (PFS2) in patients with BRCA-mutated disease (26.1 months versus 18.4 […]
Drugmaker Pulls Third-Line PARP Inhibitor Approval in Ovarian Cancer
Clovis Oncology has voluntarily withdrawn the indication for rucaparib (Rubraca) as a third-line treatment in BRCA-mutated ovarian cancer after an overall survival (OS) analysis showed a signal for potential harm, according to a filing with the Securities and Exchange Commission (SEC). “Based on further discussions with the FDA following submission of ARIEL4 OS data previously […]