Female Reproductive Factors Linked to COPD Risk
Female reproductive factors were associated with risk of chronic obstructive pulmonary disease (COPD), including age at menarche, number of children, miscarriage, stillbirth, and age at natural menopause, according to an analysis of three cohorts. Among nearly 300,000 women, a U-shaped association was observed between age at menarche and COPD (≤11 vs 13 years: HR 1.17, […]
Erectile Dysfunction Drugs Tied to Less Alzheimer’s Risk
Erectile dysfunction drugs were associated with reduced risk of Alzheimer’s disease, electronic health record (EHR) data from 270,000 men in the U.K. suggested. Over a median follow-up of about 5 years, men who started taking phosphodiesterase type 5 (PDE5) inhibitors were less likely to have an Alzheimer’s diagnosis than nonusers (adjusted HR 0.82, 95% CI […]
Improved Fitness May Reduce Prostate Cancer Risk
Improving cardiorespiratory fitness may lower men’s prostate cancer risk, results from a Swedish study suggested. The retrospective study showed that an overall increase in absolute cardiorespiratory fitness (as measured by changes in VO2max) was associated with a 2% reduced risk of prostate cancer incidence (HR 0.98, 95% CI 0.96-0.99), when adjusted for baseline fitness, age, […]
One Class of Antidiabetic Linked With Lower Kidney Stone Risk
One class of glucose-lowering agent may help lower the risk of kidney stones in adults with type 2 diabetes, a cohort study suggested. Adults who newly started on an SGLT2 inhibitor had a 31% lower risk of nephrolithiasis compared with those starting on a GLP-1 receptor agonist (HR 0.69, 95% CI 0.67-0.72), found Julie M. […]
Why Aren’t More Doctors Prescribing Paxlovid to High-Risk Patients?
Recent evidence is piling up that many people at high risk for severe COVID-19 don’t receive nirmatrelvir/ritonavir (Paxlovid) — or any outpatient antiviral treatment — when diagnosed with a SARS-CoV-2 infection. MedPage Today looked at new studies and talked to experts to find out why. In a new observational study, people on Medicare who were […]
Multiple Societal Factors Contribute to High HIV Risk in Transgender Women
Homelessness, violence, incarceration, and socioeconomic discrimination are linked to a high risk of HIV in transgender women, according to the CDC’s National HIV Behavioral Surveillance Among Transgender Women (NHBS-Trans) survey. Despite engaging in high-risk behaviors, only one-third of transgender women in the survey used pre-exposure prophylaxis (PrEP) for HIV. Employment discrimination also negatively impacted transgender […]
More Evidence Linking ADT for Prostate Cancer to Adverse Neurocognitive Effects
Men treated with androgen deprivation therapy (ADT) for prostate cancer had a significantly higher risk of dementia and other neurocognitive disorders, according to a meta-analysis of more than 2.5 million patients. The magnitude of excess risk ranged from 20% for dementia to 66% for depression. The risk of Alzheimer’s disease, vascular dementia, and Parkinson’s disease […]
No Increased Risk of Suicidal Ideation With GLP-1 Drugs
Despite recent concerns to the contrary, semaglutide (Wegovy, Ozempic) carried a lower risk of suicidal ideation in patients with obesity or type 2 diabetes, according to retrospective analyses of the two patient populations. An analysis of 240,618 patients who were overweight or obese showed that those taking semaglutide — a glucagon-like peptide 1 (GLP-1) receptor […]
Study Reveals The Biggest Risk Factors For Getting Early Dementia
The Good Brigade via Getty Images Researchers have identified some key risk factors for the early development of dementia. A recent study by the University of Exeter and Maastricht University published in JAMA Neurology has identified some of the factors that can lead to early cases of dementia ― some of which may surprise you. […]
Goodbye, Appendix. Hello, Crohn’s Disease?
ORLANDO – People who undergo appendectomy may have an increased risk for the development of Crohn’s disease (CD), but not ulcerative colitis (UC), according to a systematic review and meta-analysis. The meta-analysis showed a pooled OR of 1.57 (95% CI 1.01-2.43, P<0.00001) for CD in those who had gotten surgery of the mucosa-and-gut lymphoid tissue […]