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For Septic Shock, Another Toss-up Between Emphasizing Vasopressors Vs Fluids

SAN FRANCISCO — For sepsis-induced hypotension, a restrictive fluid strategy with earlier vasopressor use didn’t impact mortality compared with liberal fluids, the CLOVERS trial showed. The restrictive strategy had its intended effect, reducing median IV fluids administered over 24 hours by 2,134 mL in favor of more vasopressor use compared with the liberal fluids strategy […]

More Anti-Lockdown Protests In China Triggered By Deadly Fire

TAIPEI, Taiwan (AP) — Protests against China’s restrictive COVID-19 measures appeared to roil in a number of cities Saturday night, in displays of public defiance fanned by anger over a deadly fire in the western Xinjiang region. Many protests could not be immediately confirmed, but in Shanghai, police used pepper spray to stop around 300 […]

Less Fluid Not Better for Septic Shock

A more restrictive protocol for IV fluids didn’t reduce mortality for adults in the ICU receiving treatment for septic shock, the CLASSIC trial showed. Restricting IV crystalloid fluids to small boluses only for severe hypoperfusion, to replace documented fluid losses, or for dehydration and electrolyte deficiency for patients who couldn’t take fluids enterally yielded a […]

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