How Can the U.S. Avoid Another COVID-19 Stockpile Disaster?
WASHINGTON — What can be done to prevent poor federal responses to disasters, such as the Strategic National Stockpile (SNS) that was woefully under-stocked when COVID-19 hit? That’s the question addressed in a new report from the National Academies of Sciences, Engineering, and Medicine (NASEM). Responding to public health emergencies has largely been under the […]
Metabolic changes in plasma and immune cells associated with COVID-19 severity, can predict patient survival
COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death. After examining the blood samples from nearly 200 COVID-19 patients, researchers have uncovered underlying metabolic changes that regulate how immune cells react to the disease. These changes are associated with disease severity and could be used to […]
New research provides clues to developing better intranasal vaccines for COVID-19 and flu
While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear. New research published this week in mBio,an open-access journal of the American Society for Microbiology, explores the role of nasal bacteria and […]
Anti-CD7 CAR-T Therapy Yields High Response Rate in Acute Leukemia
Donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell therapy led to complete responses in 18 of 20 patients with relapsed or refractory (r/r) T-cell acute lymphoblastic leukemia (ALL), a first-in-human clinical trial showed. After a median follow-up of 6.3 months, 15 of the 18 responding patients remained in remission, and seven patients had undergone stem-cell transplantation […]