‘Game Changer’ in NASH: Resmetirom Hits Endpoints in Pivotal Study
VIENNA — The investigational agent resmetirom resolved liver biopsy findings in nonalcoholic steatohepatitis (NASH) more often than placebo, according to the phase III MAESTRO-NASH trial. While 10% of placebo patients achieved resolution of inflammation, ballooning, and disease activity, the rate was 26% among people treated with the 80-mg dose of resmetirom and 30% with the […]
When macrophages let off steam: Changes in cell metabolism protect macrophages from overloading and thus assist the resolution of inflammatory reactions
New data from a research team at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) shows how inflammatory reactions can be resolved by changes to the metabolism of macrophages. Danger signals released by damaged cells during inflammation play a role during this process. ‘Rewiring’ the mitochondria in the macrophages protects them against overloading and can thus improve the way in […]
One GI Symptom Stuck Around Months After Severe COVID
While most gastrointestinal (GI) symptoms resolved for patients hospitalized with COVID-19, inability to gain weight persisted for months, researchers found in a retrospective study. Half of all patients (50.6%) could not regain weight at 3 months, while 32.4% of patients reported an inability to gain weight 6 months later, reported Arvind J. Trindade, MD, from […]