Testosterone for Hypogonadism Cleared So Far of Prostate Cancer Risk
Men treated with testosterone replacement therapy (TRT) for hypogonadism didn’t have an increase in adverse prostate events, the TRAVERSE trial found. Over a mean follow-up of 33 months, those who used topical 1.62% testosterone gel had a 0.19% incidence of high-grade prostate cancer (Gleason score ≥4 + 3), similar to the 0.12% among placebo-treated men […]
Reassuring Registry Data on Going Into TAVR Sans Symptoms
Transcatheter aortic valve replacement (TAVR) got some preliminary affirmation for asymptomatic or minimally symptomatic severe aortic stenosis in a retrospective registry study. Of participants who got elective TAVR, the one in five who had minimal symptoms before the procedure tended to have good outcomes that compared favorably against the majority of more symptomatic peers: Fewer […]
PPI Still Common With Self-Expanding TAVR
Need for a pacemaker after transfemoral transcatheter aortic valve replacement (TAVR) with a self-expanding device was both common and impactful for mortality, but the risk appeared to be modifiable, international registry data showed. Of patients treated with an Acurate neo/neo2 (approved outside the U.S.) or Evolut PRO/PRO+ valve, 11.3% needed new permanent pacemaker implantation (PPI) […]
Real-World Data Affirms Next-Gen TAVR Device Advantage
PHOENIX — The newer generation Evolut transcatheter aortic valve replacement (TAVR) device improved on procedural and possibly safety characteristics, the TVT registry showed. The Evolut FX device reduced need for device repositioning and cut procedure time, without a change in valve hemodynamics, at 30 days compared with the Evolut Pro+ device, reported Wah Wah Htun, […]
Skipping Antiplatelets Altogether Not Such a Bad Idea for Select TAVR Patients
Following transcatheter aortic valve replacement (TAVR), the optimal antithrombotic regimen for some people may be no antithrombotics at all, according to provocative registry data from Japan. Compared with the single antiplatelet (SAPT) or dual antiplatelet (DAPT) approaches for TAVR patients without any other indications for antiplatelet or anticoagulation therapy, the non-antithrombotic strategy was not associated […]
Promising Results in First Test of In Utero Enzyme-Replacement Therapy
The first test of in utero enzyme replacement therapy (ERT) proved safe and effective for a baby with infantile-onset Pompe disease, according to a case report. An infant with cross-reactive immunologic material (CRIM)-negative infantile-onset Pompe disease — the most severe end of the disease spectrum — had no cardiac manifestations following treatment, compared to her […]
Good, and Safe, Results Tied to Oral Testosterone in Men With Deficiency
MIAMI — Oral testosterone replacement therapy (TRT) seemed safe and effective in men with testosterone deficiency, according to a meta-analysis. Among nine studies that looked at changes in serum total testosterone, only men with testosterone deficiency who took an oral agent — predominantly testosterone undecanoate — saw a significant increase in total testosterone, with a […]
Is TAVR in Small Aortic Annuli Better With Self-Expanding Valves?
BOSTON — Transcatheter aortic valve replacement (TAVR) in patients with small aortic annuli had better hemodynamic results with a self-expandable than a balloon-expandable valve, with suggestion of better clinical outcomes too, in the France-TAVI registry. Mean gradient was significantly lower with self-expanding Medtronic CoreValve Evolut Pro or R devices at the end of the procedure […]
Does Hormone Replacement Therapy Up Breast Cancer Recurrence? – MedicineNet Health News
Latest Cancer News By Steven Reinberg HealthDay Reporter THURSDAY, July 21, 2022 Hormone replacement therapy (HRT) for breast cancer survivors doesn’t appear to increase the risk of cancer recurrence or death, Danish researchers report. Although HRT has previously been linked to a raised risk of breast cancer‘s return, those earlier studies referred to oral HRT […]
Timing of heart surgery crucial, research shows
Valve replacement heart surgery should be performed earlier than conventionally thought for people with aortic stenosis — according to new research from the University of East Anglia. The condition is one of the most common and serious valve disease problems, caused by a narrowing of the aortic valve opening. Once patients develop symptoms such as […]