Older Surgical Procedure for Pelvic Prolapse Repair Prevails in Randomized Trial
A long-time surgical standard for pelvic organ prolapse repair prevailed in a comparison against a newer technique that currently predominates in some parts of the world. Sacrospinous hysteropexy failed to meet noninferiority criteria versus the Manchester procedure for the primary composite outcome of treatment success, with the latter achieving success in 87.3% of patients compared […]
Transfascial Mesh Fixation During Complex Hernia Repairs: To Skip or Not to Skip?
Not fixating the mesh in open retromuscular ventral hernia repair (RVHR) was noninferior to fixation, a single-center clinical trial found. Hernia recurrence rates at 1 year were similar between the transfascial suture fixation group versus the no fixation group (7.4% vs 9.2%, respectively, P=0.70), according to Ajita Prabhu, MD, of the Cleveland Clinic Center in […]
TEER Improves Quality of Life With Severe Tricuspid Regurgitation
NEW ORLEANS — Transcatheter edge-to-edge repair (TEER) of severely regurgitant tricuspid valves improved outcomes, largely in terms of quality of life, the TRILUMINATE Pivotal trial showed. Compared with medical therapy alone, the percutaneous placement of an investigational TriClip device to hold the leaflets together was favored in a Bayesian analysis with a win ratio of […]
Mitral Valve Repair Devices Go Head-to-Head, and the Top Spot Belongs to…
BOSTON — The Pascal device for edge-to-edge mitral valve repair was as safe and effective as the MitraClip device, the pivotal CLASP IID trial showed. In a pre-specified interim analysis of the first 180 patients enrolled, Pascal was non-inferior for the primary effectiveness endpoint of proportion of patients with mitral regurgitation no worse than 2+ […]
Study Leaves Transvaginal Mesh Controversy at Impasse
Transvaginal mesh proved noninferior to native tissue repair for vaginal prolapse but missed the superiority target in an FDA-mandated, postmarket, prospective parallel-cohort study. The 36-month composite treatment success rates were 89.3% with mesh repair and 80.2% with native tissue repair, falling within the prespecified 12% margin for noninferiority but not achieving superiority. However, mesh demonstrated […]
Cell Therapy Safe and Effective in Women with Prior Urinary Incontinence Surgery
Autologous muscle derived cells for urinary sphincter repair (AMDC-USR) to treat stress urinary incontinence (SUI) was safe and durable, particularly for women who have undergone prior SUI surgery, a researcher reported. In a randomized phase III study, 36.9% of women receiving AMCD-USR achieved a strong response (≥75% reduction in stress incontinence episode frequency at 12 […]
Hernia Surgery Went Well. Then Why Did the Patient Regret Having It?
About one in 10 patients undergoing hernia repair surgery expressed misgivings afterward, with no obvious reason, researchers found. So, what might be the unobvious reasons? That was the question Ryan Howard, MD, and colleagues at the University of Michigan in Ann Arbor sought to address, though their initial attempt to pierce the mystery fell short […]
Championing chrononutrition with protein, the morning elixir for muscle growth
Proteins constitute an essential dietary component that help in the growth and repair of the body. Composed of long chains of amino acids, proteins promote the growth of skeletal muscles, the group of muscles that help us move. Humans have been aware of the benefits of proteins for long. However, recent studies have shown that […]