Clinical Challenges: Secondary CNS Relapse in Diffuse Large B-Cell Lymphoma
Central nervous system (CNS) relapse occurs in roughly one in 20 patients with diffuse large B-cell lymphoma (DLBCL), but in some disease subtypes that risk increases substantially. “In certain subsets of patients, the risk is quite low, but in others it can be quite high so it is better to focus on the high-risk groups,” […]
Progression Independent of Relapse Activity in Pediatric-Onset MS
Pediatric-onset multiple sclerosis (MS) patients showed progression independent of relapse activity (PIRA) even when they were relatively young, a prospective cohort study found. Confirmed PIRA events within 48 weeks of baseline occurred in 40.4% of pediatric-onset MS patients and were more frequent in older-onset groups, reported Maria Pia Amato, MD, of the University of Florence […]
Efgartigimod Offers Hope in Chronic Inflammatory Demyelinating Polyneuropathy
PHOENIX — A subcutaneous infusion of efgartigimod cut the risk of relapse in patients with a rare but serious immune-mediated neuropathy, according to the phase II ADHERE trial. Patients with diagnosed chronic inflammatory demyelinating polyneuropathy (CIDP) treated with efgartigimod alfa and hyaluronidase-qvfc (Vyvgart Hytrulo) saw a 61% reduction in the risk of relapse versus placebo, […]
Newly identified neuromarker reveals clues about drug and food craving
Craving is known to be a key factor in substance use disorders and can increase the likelihood of future drug use or relapse. Yet its neural basis — or, how the brain gives rise to craving — is not well understood. In a new study, researchers from Yale, Dartmouth, and the French National Centre for […]
Immune protein may drive alcoholism relapse
The anxiety that occurs during withdrawal from excessive alcohol use, and contributes to relapse, may be driven in part by the release of an immune protein in the brain, according to a new study from scientists at Scripps Research. The discovery, reported online June 6, 2022, in Molecular Psychiatry, illuminates the molecular details of the […]