Monoclonal Antibodies Linked to Reduced RSV Burden in Young Kids
Prophylactic use of three monoclonal antibodies was associated with substantial reductions in respiratory syncytial virus (RSV)-related infections and hospitalizations in children under 5, a systematic review and meta-analysis showed. Across 14 randomized controlled trials involving over 18,000 high-risk children, moderate- to high-certainty evidence showed that nirsevimab, palivizumab, and motavizumab were associated with significant reductions in […]
Pre-Op Axitinib Helps for Partial Nephrectomy of Complex Renal Tumors
SAN DIEGO — Use of neoadjuvant axitinib (Inlyta) resulted in significant reductions in tumor size and complexity, enabling partial nephrectomy in a cohort of patients with highly complex renal masses in whom the procedure would ordinarily not be feasible, according to an interim analysis from a small phase II trial. A course of the tyrosine […]
Testosterone Tied to Sustained Weight Loss in Men With Hypogonadism and Obesity
SAN DIEGO — Long-term testosterone therapy was associated with sustained reductions in weight for men with hypogonadism and class III obesity, a researcher reported. In registry data on 76 patients, those who opted to receive testosterone undecanoate experienced a 26% reduction in their body mass index (BMI) over close to a decade of follow-up, reported […]
Low-Dose Cariprazine for MDD Tied to Anxiety Reduction
NEW ORLEANS — Low-dose cariprazine (Vraylar) was associated with reductions in anxiety for patients with major depressive disorder (MDD), and the potential adjunctive therapy for this population also demonstrated improvements across most individual symptoms of depression, according to two post hoc analyses of a phase III trial. When combined with an antidepressant for MDD patients […]
Brain Volumes Shrink With One Daily Drink
Light to moderate alcohol consumption — as few as one or two drinks a day — was linked with reductions in overall brain volume, a cross-sectional study showed. Among nearly 37,000 healthy adults in the U.K. Biobank, alcohol intake was negatively associated with global brain volume measures, regional gray matter volumes, and white matter microstructure, […]