Study Examines Off-Target Mortality in Cancer Screening
Cancer screening reduced targeted cancer mortality without significantly increasing deaths from other causes. Meta-analysis of 17 studies found a 0.2% increase in off-target mortality rates in screened patients. Results suggest a need to analyze on-target cancer mortality and off-target mortality separately in trials of cancer screening. Screening for cancer reduced targeted cancer mortality without a […]
Use of Video Laryngoscopy Reduced Endotracheal Intubation Attempts
Use of hyperangulated video laryngoscopy reduced the number of attempts needed to achieve endotracheal intubation compared with direct laryngoscopy among adults undergoing elective or emergent surgical procedures, a cluster randomized trial showed. At a single academic hospital, more than one intubation attempt was required in 1.7% of the procedures in which video laryngoscopy was used […]
A healthier diet is linked with a slower pace of aging, reduced dementia risk, study shows
A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study at Columbia University Mailman School of Public Health and The Robert Butler Columbia Aging Center. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. While literature had […]
Semaglutide Cuts Liver Disease Severity in People With HIV
DENVER — Semaglutide (Ozempic) reduced the amount of liver fat by nearly a third in people with HIV and metabolic dysfunction-associated steatotic liver disease (MASLD), the open-label phase IIb SLIM LIVER study showed. In the single-arm trial, the absolute change in intrahepatic triglyceride (IHTG) content across all participants was -4.2% (95% CI -5.4 to -3.1, […]
Semaglutide Reduced Inflammatory Biomarkers in HIV Patients With Lipohypertrophy
DENVER — People with HIV who received semaglutide (Ozempic, Wegovy) had reduced levels of several inflammatory biomarkers associated with cardiovascular disease, a randomized controlled trial showed. After 32 weeks, interleukin (IL)-6 levels decreased by 18.8%, high-sensitivity C-reactive protein (hsCRP) levels decreased by 39.9%, and soluble CD163 levels decreased by 12.3% with the GLP-1 receptor agonist, […]
Novel Antibody for Chronic Hives Brings Relief in Mid-Stage Trial
WASHINGTON — Barzolvolimab, a first-in-class anti-KIT monoclonal antibody, reduced the severity of hives in adults with chronic spontaneous urticaria (CSU) who remained symptomatic on antihistamines, a randomized phase II trial showed. Compared with placebo, several doses of the investigational drug produced greater improvement in the 7-day Urticaria Activity Score (UAS7) from baseline to week 12: […]
Dupilumab Cuts Lung Inflammation, Breaks Up Mucus Plugs in Asthma Patients
WASHINGTON — Dupilumab (Dupixent) reduced airway inflammation and increased lung capacity in patients with uncontrolled, moderate-to-severe asthma, while also reducing troublesome mucus plugs, a multinational postmarketing study showed. In the randomized study, treatment with dupilumab led to significant reductions in airway inflammation at 24 weeks, with 57% achieving a fractional exhaled nitric oxide (FeNO) level […]
Another Study Backs Treatment for Preclinical Rheumatoid Arthritis
Inflammatory markers were reduced in patients with persistent joint pain and other markers for incipient rheumatoid arthritis (RA), as was progression to formal RA diagnosis, after a 6-month course of abatacept (Orencia) in a placebo-controlled trial. While 35% of controls were diagnosed with RA while on treatment in the trial, called ARIAA, only 8% of […]
Embolization Proves Its Mettle for Subdural Hematoma
PHOENIX — For chronic or subacute subdural hematoma, embolization of the middle meningeal artery (MMA) reduced recurrence, three randomized trials showed. Two trials with the Onyx liquid embolic system and one with the Squid liquid embolic system were reported with what one presenter called “very consistent” findings at the closing late-breaking science session of the […]
Erectile Dysfunction Drugs Tied to Less Alzheimer’s Risk
Erectile dysfunction drugs were associated with reduced risk of Alzheimer’s disease, electronic health record (EHR) data from 270,000 men in the U.K. suggested. Over a median follow-up of about 5 years, men who started taking phosphodiesterase type 5 (PDE5) inhibitors were less likely to have an Alzheimer’s diagnosis than nonusers (adjusted HR 0.82, 95% CI […]