Dupilumab May Help in Tough-to-Treat Chronic Spontaneous Urticaria
PHOENIX — Patients who received add-on dupilumab (Dupixent) treatment for chronic spontaneous urticaria (CSU) had reduced symptoms and experienced less itchiness, a phase III trial found. In the 6-month study, participants (adults, adolescents, and children) treated with dupilumab on top of their usual H1-antihistamine (H1-AH) experienced a 4.2-point greater mean reduction in their Itch Severity […]
Alternative technique for determining the true activity of catalysts: Researchers from Japan perform reliable estimation of the activity of water-splitting catalysts with an unconventional technique
Electrolysis of water or “water electrosplitting” has received a great deal of attention recently owing to its potential as a clean source of hydrogen, the oft-touted fuel of the future. However, two issues have long stood in the way: the large amount of energy lost, and the cost of electrocatalysts (catalysts used for electrolysis). Fortunately, […]
Double vaccination halves risk of long COVID, study finds
Adults who have received a double vaccination are 49% less likely to have Long COVID should they contract a COVID-19 infection, a new study finds. Researchers at King’s College London analysed data from participants logging their symptoms, tests and vaccines on the UK ZOE COVID Symptom Study app between 8th December 2020 and 4 July […]
Distress signal from fat cells prompts heart to shore up defenses against consequences of obesity
A stress signal received by the heart from fat could help protect against cardiac damage induced by obesity, a new study led by UT Southwestern researchers suggests. The finding, published online in Cell Metabolism, could help explain the “obesity paradox,” a phenomenon in which obese individuals have better short- and medium-term cardiovascular disease prognoses compared […]
CDC Panel Backs Third COVID Shot for the Immunocompromised
Moderately to severely immunocompromised people who received mRNA vaccines for COVID-19 should receive an additional dose, the CDC’s Advisory Committee on Immunization Practices (ACIP) said on Friday. In a unanimous 11-0 vote, the ACIP recommended an additional dose of the Pfizer (ages 12 and up) or Moderna vaccine (ages 18 and up) following a primary […]
Slow Going With CAR T-Cell Therapy for Solid Tumors
Almost 4 years after the first chimeric antigen receptor (CAR) T-cell therapies received FDA approval, the transformative impact of the treatment on refractory hematologic malignancies has yet to translate into the field of solid tumors. The increased molecular complexity of solid tumors and lack of good antigen targets have coalesced into a formidable roadblock for […]
Novel Drug Helped HIV Patients Achieve Viral Suppression
More than 80% of heavily treatment-experienced HIV patients with multi-drug resistance who received long-acting subcutaneous lenacapavir along with an optimized background regimen experienced viral suppression at week 26, according to results of an ongoing randomized phase II/III trial. Overall, 81% of patients randomized to the investigational agent lenacapavir with an optimized background regimen of antiretroviral […]
FDA to Add Warning on Rare Myocarditis Risk After COVID Vaccination
Given the reported cases of myocarditis in young people who received mRNA COVID-19 vaccines, FDA will include a warning statement about the risks and characteristics of this rare condition, an agency representative said at CDC’s Advisory Committee on Immunization Practices (ACIP) meeting on Wednesday. Data presented by CDC staff estimated a rate of 12.6 cases […]