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Raludotatug Deruxtecan Promising in Platinum-Resistant Advanced Ovarian Cancer

SAN DIEGO — Treatment with raludotatug deruxtecan (R-DXd) led to an “exciting” response rate among patients with heavily pretreated, platinum-resistant advanced ovarian cancer, according to an early-phase trial. In a subgroup analysis of the first-in-human phase I study, there was one complete response and 17 partial responses among 37 evaluable patients treated with R-DXd, an […]

Noninvasive Therapy Shows Efficacy in Non-Muscle-Invasive Bladder Cancer

WASHINGTON — An investigational non-surgical treatment led to a “robust” complete response rate in patients with recurrent, low-grade non-muscle-invasive bladder cancer, the phase III ENVISION study showed. Patients treated with the UGN-102 (mitomycin) intravesical solution achieved a complete response rate of 79.2% (95% CI 73.5-84.1) at 3 months without having to undergo transurethral resection of […]

Apixaban Prophylaxis Fails to Reduce Clots in Pediatric ALL

Prophylaxis with apixaban (Eliquis) failed to reduce the rate of venous thromboembolism (VTE) in children with newly diagnosed acute lymphoblastic leukemia or lymphoma, according to results from the phase III randomized PREVAPIX-ALL study. During a median follow-up of 27 days, 12% of patients receiving the direct oral anticoagulant had a composite VTE compared with 18% […]

CDC Reports Record High Rate Of Vaccine Exemptions For Kindergartners

LOADINGERROR LOADING The exemption rate for routine vaccinations among kindergartners has reached a record high, according to the Centers for Disease Control and Prevention. A CDC report released Thursday said 3% of children in kindergarten during the 2022-23 school year were granted a nonmedical vaccine exemption from their state. That rate, an increase from the […]

Should ‘Site Neutrality’ Be Used to Set Payments? MedPAC Members Disagree

Should “site neutrality” — the idea of paying the same rate for the same service no matter where it is provided — be applied when it comes to setting Medicare payment rates? Nope, says Medicare Payment Advisory Commission (MedPAC) member Lynn Barr, MPH. “I don’t think ‘site-neutral’ is neutral,” Barr, of the Barr-Campbell Family Foundation […]

Fat burning during exercise varies widely between individuals: Study reveals limitations of commercial exercise machines, emphasizing the need for a more personalized approach to exercise

The best heart rate for burning fat differs for each individual and often does not align with the “fat burning zone” on commercial exercise machines, Icahn School of Medicine at Mount Sinai researchers report. Instead, the researchers said, clinical exercise testing — a diagnostic procedure to measure a person’s physiological response to exercise — may […]

AI-Backed Mammography Keeps Up With Docs for Cancer Detection

Artificial intelligence-supported mammography resulted in a cancer detection rate comparable to that of two breast radiologists working together, while also substantially cutting screening workload. Among more than 80,000 women randomized to either AI-supported mammography screening or to standard double reading without AI, cancer detection rates were 6.1 (95% CI 5.4-6.9) per 1,000 screened participants in […]

Lean body mass, age linked with alcohol elimination rates in women

The rate at which women eliminate alcohol from their bloodstream is largely predicted by their lean body mass, although age plays a role, too, scientists found in a new study. Women with obesity — and those who are older — clear alcohol from their systems 52% faster than women of healthy weights and those who […]

Kid Homicides Surge in COVID; Physician Work Hours Drop; Vasectomies Up Post-Roe?

Note that some links may require subscriptions. The U.S. child homicide rate has been increasing around 4% each year since 2013, but skyrocketed by 28% during the first year of the pandemic. (JAMA Pediatrics) Firearm injuries among kids also surged by 52% during COVID, according to a research letter in JAMA Pediatrics. An independent review […]

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