Benzodiazepines Tied to Worse Outcomes in Progressive Supranuclear Palsy
People with progressive supranuclear palsy (PSP) who were prescribed benzodiazepine derivatives had a faster decline in PSP Rating Scale (PSPRS) scores than those who didn’t have benzodiazepines, a post hoc analysis showed. In a secondary analysis of concomitant drugs used in a phase II/III clinical trial, only one medication class — benzodiazepine derivatives, including lorazepam, […]
America’s Loneliness Epidemic Is Fueling The Far Right, Sen. Chris Murphy Says
Sen. Chris Murphy (D-Conn.) is a mainstream progressive known for supporting a tougher U.S. approach to Saudi Arabia and stricter gun safety regulations. In December, though, he began taking up a cause not typically on Congress’ agenda: an epidemic of loneliness in the United States that Murphy believes is quietly at the heart of the […]
Heterogeneous development of beta-cell populations in diabetes-resistant and -susceptible mice
Progressive dysfunction and failure of insulin-releasing β-cells is a hallmark of type 2 diabetes (T2D). DZD researchers have now shown that diabetes resistant and -susceptible mice respond differently to a carbohydrate-rich diet. The gene expression of the beta cells of the diabetes-resistant mice changed in such a way that a protective beta cell cluster developed. […]
Muscle biopsy test for biomarker could lead to earlier diagnosis of ALS
Amyotrophic lateral sclerosis (ALS) is a progressive disease of the nervous system. It affects nerve cells in the brain and spinal cord called motor neurons. Motor neurons control muscle movement and ALS causes them to deteriorate and eventually die. The motor neurons lose the ability to send messages to the muscles in the body, affecting […]
FDA Approves First Targeted Radioligand Therapy for Metastatic Prostate Cancer
On Wednesday, the FDA approved the first targeted therapeutic radioligand for progressive, metastatic castration-resistant prostate cancer (mCRPC) with prostate-specific membrane antigen (PSMA) expression. Consisting of a targeting compound and a therapeutic radioisotope, lutetium Lu 177 vipivotide tetraxetan (Pluvicto) hones in on PSMA-expressing mCRPC, as identified by a companion diagnostic test (gallium Ga 68 Gozetotide injection, […]
Deep Learning Identifies PPMS Patients Who May Respond to Treatment
Deep learning identified subgroups of patients with primary progressive multiple sclerosis (PPMS) who may respond to disease-modifying therapy, researchers said. A trained model separated responders and non-responders across a range of predicted effect sizes, reported Jean-Pierre Falet, MD, of McGill University in Montreal, Canada, at the ACTRIMS Forum 2022, the annual meeting of the Americas […]