FDA OKs First Cellular Therapy for Melanoma
The FDA approved the cellular therapy lifileucel (Amtagvi) for the treatment of patients with previously treated unresectable or metastatic melanoma, the agency announced Friday. Lifileucel, a cellular therapy with tumor-infiltrating lymphocytes (TILs), was approved through the accelerated approval pathway, and is the first FDA-approved tumor-derived T-cell immunotherapy, the FDA noted. “Unresectable or metastatic melanoma is […]
Emicizumab Safe, Effective, in Infants With Hemophilia A
SAN DIEGO — Administering emicizumab (Hemlibra) to previously untreated or minimally treated infants with severe hemophilia A without factor VIII inhibitors is effective and safe, according to results from research presented here. The phase III HAVEN-7 study showed that at a median follow-up of 101.9 weeks, the annualized treated bleeding rate was 0.4 (95% CI […]
Allergic responses to common foods could significantly increase risk of heart disease, cardiovascular death
Sensitivity to common food allergens such as dairy and peanuts could be an important and previously unappreciated cause of heart disease, new research suggests — and the increased risk for cardiovascular death includes people without obvious food allergies. That increased risk could be comparable to — or exceed — the risks posed by smoking, as […]
Seth Rogen’s Wife Lauren Miller Reveals Hospitalization For Brain Aneurysm
LOADINGERROR LOADING Lauren Miller is sharing her story about an alarming health discovery she previously faced. The actor and comedian unexpectedly revealed at the University of California, Los Angeles’s (UCLA) Neurosurgery Visionary Ball in Beverly Hills this week that she had a brain aneurysm — and only found it after being inspired by the “Hilary […]
Vascular Conditions Offer No Clarity on Pollution-Dementia Link
Investigators appeared to rule out vascular dysfunction mediating the previously reported link between fine particulate matter (PM2.5) and dementia. Contrasting with prior studies, their nationally representative U.S. cohort study found no significant association between greater long-term exposure to PM2.5 and a higher dementia risk 10 years later (HR 1.04, 95% CI 0.98-1.11). Sensitivity analysis suggested […]
Yogurt may be the next go-to garlic breath remedy
It turns out yogurt may have a previously unknown benefit: eliminating garlic odors. A new study conducted in a lab — with follow-up human breath tests being planned — showed that whole milk plain yogurt prevented almost all of the volatile compounds responsible for garlic’s pungent scent from escaping into the air. Researchers tested the […]
Resistant starch supplement reduces liver triglycerides in people with fatty liver disease
Resistant starch is a nondigestible fiber that ferments in the large intestine, and consumption of it has previously been shown to have a positive effect on metabolism in animal studies. Now, a 4-month randomized controlled trial in people with non-alcoholic fatty liver disease (NAFLD) indicates that daily intake of resistant starch can alter gut bacteria […]
Small Gains in Cardiorespiratory Fitness Track With Improved Longevity
As previously suspected, changes in cardiorespiratory fitness (CRF) were associated with reciprocal changes in mortality risk independent of other comorbidities or initial fitness status, a large observational study found. People who had serial exercise treadmill test assessments, with a median 6 years between initial and final tests, showed that changes in aerobic capacity over time […]
Cardiac Arrest Growing More Common in the Delivery Room?
Cardiac arrest during labor and delivery appeared more common than previously seen — particularly for older, Black, and low-income pregnant patients — but with better survival rates, according to a national study. Among women admitted for delivery in the National Inpatient Sample (NIS) from 2017 to 2019, cardiac arrest occurred in about one in 9,000 […]
Persistent Lymphadenopathy and Neck Abscesses in a Healthy Boy
What was causing this previously healthy 12-year-old boy to have nasal obstruction, increasing hoarseness and difficulty speaking, tender and swollen lymph nodes on his neck and recurring deep neck abscesses? That’s the question Samantha M. Moore, BS, of the Medical College of Wisconsin in Milwaukee, and colleagues tackled in a case reported in JAMA Otolaryngology–Head […]