Primary Care Strategy Fails to Reduce Kidney-Dysfunction Triad Hospitalizations
Using a personalized algorithm to identify primary care patients with chronic kidney disease (CKD), type 2 diabetes, and hypertension (the kidney-dysfunction triad) — plus practice facilitators to help providers deliver guideline-based interventions — didn’t move the needle for reducing hospitalizations, the ICD-Pieces study found. At 1 year, the hospitalization rate of patients in the intervention […]
High-Dose Leptin Reversed Severe Genetic Obesity in Two Patients
Personalized recombinant leptin treatment helped reverse severe, early-onset obesity in two children carrying rare antagonistic leptin genetic variants, a study showed. In the double case report, two unrelated children — a 14-year-old boy and a 2-year-old girl — presented with what appeared to be leptin dysfunction, marked by intense hyperphagia, lack of satiety, and severe […]
Personalized Cancer Vaccine Boosts Recurrence-Free Survival in Melanoma
ORLANDO — Adding a personalized cancer vaccine to anti-PD-1 immunotherapy for resectable melanoma led to a 44% improvement in recurrence-free survival (RFS) versus immunotherapy alone, according to a study reported here. Patients who received the mRNA vaccine, derived from their own tumor, had an 18-month RFS of 78.6% as compared with 62.2% for patients who […]
Dietary fiber is good for you, except when it’s not: Researchers uncover the role of dietary fiber and gut microbes in people with inflammatory bowel disease, a finding which could lead to personalized dietary guidelines
People who suffer from inflammatory bowel disease may soon have access to personalized dietary guidelines to keep them feeling well, thanks to new research on how dietary fibre affects the disease. The research team discovered that certain types of dietary fibre cause an inflammatory response in some patients, causing symptoms to worsen. They are now […]