Fat cells help repair damaged nerves
Damage to the body’s peripheral nerves can cause pain and movement disorders. Researchers at the Leipzig University have recently investigated how damaged nerves can regenerate better. They found that fat tissue strongly supports the Schwann cells needed for repair during the healing process. The results were published in the journal Cell Metabolism. Our bodies are […]
Proteins Predict Signs of Alzheimer’s Disease
Protein indicators of subclinical peripheral heath in plasma were linked with markers of Alzheimer’s disease and neurodegeneration, cross-sectional proteomic analyses showed. Greater protein-based risk for cardiovascular disease, heart failure mortality, and kidney disease was associated with plasma biomarkers of amyloid-beta, phosphorylated tau181 (p-tau181), neurofilament light (NfL, a measure of neuronal injury), and glial fibrillary acidic […]
Supplementation with amino acid serine eases neuropathy in diabetic mice
Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy — weakness, numbness, and pain, primarily in the hands and feet. The condition occurs when high levels of sugar circulating in the blood damage peripheral nerves. Now, working with mice, Salk Institute researchers have identified another factor contributing to diabetes-associated peripheral […]
Lithotripsy Advantage in Calcified Peripheral Vessels Holds Up at 1 Year
ATLANTA — Intravascular lithotripsy (IVL) beat percutaneous transluminal angioplasty (PTA) for keeping calcified peripheral artery lesions open at 1 year, the Disrupt PAD III trial showed. Primary patency at 1 year was 80.5% for the IVL arm compared with 68.0% for the PTA arm (P=0.017), reported William Gray, MD, co-director of the Lankenau Heart Institute […]
Home Walking Program Eases Peripheral Artery Disease Limitations
Motivating patients with peripheral artery disease (PAD) and intermittent claudication to start walking at home improved their exercise capacity, the MOSAIC trial showed. Six-minute walk distance improved by 16.7 m more with the physical therapist-led intervention compared with usual care alone at 3 months (from 352.9 m at baseline to 380.6 m vs 369.8 to […]
Peripheral Nerve Problems Tied to Later Dementia
Peripheral nerve impairments in older adults were tied to a higher risk of subsequent dementia, a study of longitudinal data showed. Combined sensory and motor impairments in the lower leg doubled the risk of subsequent dementia (HR 1.92, 95% CI 1.29-2.88) compared with people who had no leg impairments, reported Willa Brenowitz, PhD, MPH, of […]