SPRINT BP Control Ups cTn; FH & Eating Disorders; Cardiac Death During ‘Avatar 2’
In SPRINT, intensive systolic blood pressure lowering decreased natriuretic peptide levels but increased high-sensitivity cardiac troponin T (cTn). (Circulation) The medical community braces for harmful messaging about COVID-19 vaccines after Florida Surgeon General Joseph Ladapo, MD, PhD, announced plans for another study on their links to myocarditis. (Orlando Sentinel) As an alternative to high-intensity statin […]
CEND-1 Offers Hope in Advanced Pancreatic Cancer
Chemotherapy combined with the CEND-1 cyclic peptide showed promising efficacy, and was well tolerated as a first-line treatment, for patients with metastatic pancreatic cancer, researchers reported. In a phase I study of 29 patients evaluable for efficacy, 59% (95% CI 39-77) responded to the combination of CEND-1 — a novel 9-amino acid cyclic peptide that […]
Intranasal Zavegepant Shows Promise in Acute Migraine
Zavegepant, an investigational nasal spray formulation of a small-molecule calcitonin gene-related peptide (CGRP) receptor antagonist, met its co-primary endpoints in a phase III randomized placebo-controlled trial of acute migraine. On both primary endpoints — 2-hour pain freedom (23.6% vs 14.9%, P<0.0001) and 2-hour freedom from most bothersome symptom (39.6% vs 31.1%, P=0.0012) — zavegepant was […]
Novel Migraine Prevention Drug Wins FDA Nod
Atogepant (Qulipta) became the first oral calcitonin gene-related peptide (CGRP) receptor antagonist (gepant) specifically developed for migraine prevention to win FDA approval, AbbVie announced Monday. The drug earned a nod for prevention of episodic migraine in adults and became the second gepant approved for migraine prevention. The first, rimegepant (Nurtec ODT), originally was approved to […]