Near 15% Weight Loss With Novel Oral GLP-1 RA in Phase II Obesity Trial
SAN DIEGO — Orforglipron, an investigational nonpeptide GLP-1 receptor agonist, helped people with obesity lose a significant amount of weight in a phase II trial. Tested at four once-daily doses — 12, 24, 36, or 45 mg — patients on orforglipron lost between 8.6% to 12.6% of body weight compared with a 2% change seen […]
Across Borders, Worse COVID Outcomes Seen in Polluted Areas
During the pandemic, people exposed to more air pollution were at greater risk of COVID-19 infection, hospitalization, and death, a nationwide study from Denmark showed. Based on the country’s COVID-19 surveillance system covering over 3.7 million residents, there were significant associations between local levels of inhalable particulate matter (PM2.5) and nitrogen dioxide (NO2) and incident […]
Omega-3 fatty acids linked to slower decline in ALS
People with amyotrophic lateral sclerosis (ALS) who eat more foods high in certain omega-3 fatty acids like flaxseed oil, walnuts, canola oil and pumpkin seeds may have a slower physical decline from the disease and may have a slightly extended survival. The study, which looked at the survival of people with ALS over the course […]
More Than 1 Million People Dropped From Medicaid As States Start Post-Pandemic Purge
More than 1 million people have been dropped from Medicaid in the past couple months as some states moved swiftly to halt health care coverage following the end of the coronavirus pandemic. Most got dropped for not filling out paperwork. Though the eligibility review is required by the federal government, President’s Joe Biden’s administration isn’t […]
Are Athletes With T1D Putting Themselves at Risk for Recurrent Hypoglycemia?
CHICAGO – Nearly three-fourths of people with type 1 diabetes (T1D) who engaged in aerobic activity failed to follow guidelines for preventing hypoglycemia, according to a survey-based study. Guidelines state that if a person with T1D experiences severe hypoglycemia, they should not exercise for 24 hours, but 73% of those surveyed (n=102 adults) reported exercising […]
Treating Early Hospitalization Blood Pressure Deemed a No-No for Patient Safety
For older people hospitalized with noncardiovascular diagnoses, intensive lowering of asymptomatic inpatient blood pressures (BPs) may constitute overtreatment and lead to harm, observational data suggested. U.S. veterans acutely treated for elevated systolic BP in the first 48 hours of hospitalization — without evidence of acute end organ damage — suffered more adverse events when counting […]
No Access to Routine Healthcare Biggest Barrier to HPV Vaccination
BALTIMORE — People with access to routine healthcare were more likely to have received human papillomavirus (HPV) vaccination compared with those who did not have this access, a retrospective analysis of National Health and Nutrition Examination Survey data suggested. Among participants ages 12 to 26, those with health insurance and a routine healthcare provider had […]
Immune Checkpoint Inhibitors Safe, Effective in Cancer Patients With HIV
Immune checkpoint inhibitors showed activity among people with HIV and various cancer types, without any excess or unexpected toxicities, according to a retrospective real-world study. In a cohort of 390 patients with HIV and cancer, 20% had immune-related adverse events (AEs) of any grade and 7.7% had grade ≥3 immune-related AEs, reported Abdul Rafeh Naqash, […]
The feeling of hunger itself may slow aging in flies
From low-carb to intermittent fasting, surgery to Ozempic — people turn to a seemingly never-ending array of diets, procedures and drugs to lose weight. While it has been long understood that limiting the amount of food eaten can promote healthy aging in a wide range of animals, including humans, a new study from University of […]
The Biggest Warning Signs That You’re Experiencing Early Menopause
Yana Iskayeva via Getty Images Hormone therapy can be a necessary treatment for some people experiencing early or premature menopause. For half of the population, menopause is something that occurs during middle age and is a sign of the end of the reproductive years. “Menopause is a natural process that occurs in women when their […]