Surgical Remission of Cushing’s Disease Tied to New Autoimmune Conditions
Development of autoimmune disease was more common in patients with surgical remission of Cushing’s disease than in those with surgically treated nonfunctioning pituitary adenomas (NFPAs), according to a retrospective matched cohort study. At 3 years after surgery, 10.4% of patients with Cushing’s disease developed new-onset autoimmune disease compared with 1.6% of those with NFPAs (HR […]
FDA OKs First Cellular Therapy for Melanoma
The FDA approved the cellular therapy lifileucel (Amtagvi) for the treatment of patients with previously treated unresectable or metastatic melanoma, the agency announced Friday. Lifileucel, a cellular therapy with tumor-infiltrating lymphocytes (TILs), was approved through the accelerated approval pathway, and is the first FDA-approved tumor-derived T-cell immunotherapy, the FDA noted. “Unresectable or metastatic melanoma is […]
Another Study Backs Treatment for Preclinical Rheumatoid Arthritis
Inflammatory markers were reduced in patients with persistent joint pain and other markers for incipient rheumatoid arthritis (RA), as was progression to formal RA diagnosis, after a 6-month course of abatacept (Orencia) in a placebo-controlled trial. While 35% of controls were diagnosed with RA while on treatment in the trial, called ARIAA, only 8% of […]
Study: Let’s Revisit Extended Antibiotic Prophylaxis in Joint Replacement
SAN FRANCISCO — Routinely giving antibiotic prophylaxis for 10 days in arthroplasty patients apparently did nothing beyond what was achieved with shorter protocols to prevent prosthetic joint infections (PJIs) at one major medical center. PJI rates at Vanderbilt University Medical Center in Nashville were no lower after a policy was implemented in 2020 to provide […]
Late Tenecteplase Not Beneficial for Stroke Patients With LVOs
PHOENIX — Selected stroke patients did not benefit clinically from having the window of tenecteplase therapy extended beyond the first few hours of stroke onset, the randomized TIMELESS trial found. In patients with large-vessel occlusions (LVOs) and evidence of salvageable tissue on perfusion imaging — most who also received endovascular thrombectomy — functional outcomes at […]
Before Stroke Thrombectomy, Keep the Bed Flat, Trial Says
PHOENIX — For large vessel occlusion (LVO) acute ischemic stroke patients planned for mechanical thrombectomy, bed positioning made a big difference in clinical worsening, the ZODIAC trial showed. Keeping the head of the bed flat at a zero-degree angle after the CT scan while awaiting the cath lab led to 50-fold fewer cases of early […]
Potentially Protective Agent Shows Benefit in Niemann-Pick Type C
Patients with Niemann-Pick disease type C who received N-acetyl-L-leucine (NALL), an agent that potentially ameliorates lysosomal and metabolic dysfunction, showed reduced neurologic signs and symptoms after 3 months, a phase III crossover trial found. After 12 weeks of treatment, the mean change from baseline in scores on the Scale for the Assessment and Rating of […]
Most Immunocompromised Patients Clear Omicron Infections
Prolonged SARS-CoV-2 infection during the Omicron period was uncommon among patients who were moderately to severely immunocompromised, a prospective multicenter study found. Among the 150 individuals included in the analysis, 25% had prolonged infection lasting 21 days or more as detected by RT-PCR, and only 8% had a positive viral culture at 21 days or […]
Peripheral IV Access for Chemo Better Than Central Lines in Testicular Cancer?
Patients with testicular cancer had fewer venous access-related complications and overall thrombotic events when first-line chemotherapy was delivered via peripheral intravenous access compared with central venous access devices (CVADs), a retrospective study suggested. Among 154 patients, those in the CVAD group compared with the peripheral IV group experienced more venous access-related complications (52.2% vs 24.2%) […]
Perioperative Complications Not Deciding Factor Between Two Bariatric Procedures
For patients undergoing primary bariatric surgery, perioperative complications and safety were similar between laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass (RYGB), the randomized BEST trial found. Incidence of any adverse event (AE) at 30 days didn’t significantly differ, occurring in 4.6% of sleeve gastrectomy and 6.3% of RYGB patients (OR 0.71, 95% CI 0.47-1.08, […]