Skin Test Detects Parkinson’s and Other Synucleinopathies
Skin biopsies detected phosphorylated alpha-synuclein in a high proportion of people with Parkinson’s disease and other synucleinopathies. Finding a reliable diagnostic biomarker for synucleinopathies is an urgent unmet need. Further research is needed in other clinical populations to validate these findings. Skin biopsies detected cutaneous phosphorylated alpha-synuclein (p-syn) in a high proportion of people who […]
Retinal Changes Emerge Years Before Parkinson’s Disease
People with Parkinson’s disease had retinal changes that could be seen with optical coherence tomography (OCT) years before diagnosis, cross-sectional data suggested. Both incident and prevalent Parkinson’s disease were associated with reduced ganglion cell-inner plexiform layer (GCIPL) and inner nuclear layer (INL) thicknesses, reported Siegfried Karl Wagner, MSc, MD, of University College London in England, […]
Parkinson’s Biomarker Shows High Accuracy
An alpha-synuclein seed amplification assay (SAA) accurately detected Parkinson’s disease in cerebrospinal fluid (CSF) and identified people with early, non-motor symptoms prior to diagnosis, cross-sectional data from the Parkinson’s Progression Markers Initiative (PPMI) showed. Sensitivity for Parkinson’s disease overall was 87.7% and specificity for healthy controls was 96.3%, reported Andrew Siderowf, MD, of the University […]
Parkinson’s Incidence 50% Higher Than Previously Thought
The annual incidence of Parkinson’s disease was 50% higher than previous estimates in data from five epidemiological cohorts in the U.S. and Canada. The new incidence rate was nearly 90,000 cases annually for people 65 and older, reported Allison Willis, MD, of the University of Pennsylvania in Philadelphia, and co-authors. This contrasted sharply with the […]
Blood Biomarker Linked With Parkinson’s Disease
Serum neurofilament light (NfL), a measure of axonal injury, was associated with incident Parkinson’s disease, parkinsonian signs, and decline in physical functioning, a longitudinal study showed. Among 1,300 people in the Chicago Health and Aging Project (CHAP), a twofold higher concentration of serum NfL was associated with incident clinical Parkinson’s disease (OR 2.54, 95% CI […]
Risk for Parkinson’s Disease Falls After a Heart Attack
Title: Risk for Parkinson’s Disease Falls After a Heart AttackCategory: Health NewsCreated: 2/18/2022 12:00:00 AMLast Editorial Review: 2/22/2022 12:00:00 AM
‘E-nose’ could someday diagnose Parkinson’s disease by ‘smelling’ skin
Scientists have been trying to build devices that could diagnose Parkinson’s disease (PD) through odor compounds on the skin. Now, researchers reporting in ACS Omega have developed a portable, artificially intelligent olfactory system, or “e-nose,” that could someday diagnose the disease in a doctor’s office. PD causes motor symptoms, such as tremors, rigidity and trouble […]
New AI algorithm to improve brain stimulation devices to treat disease
For millions of people with epilepsy and movement disorders such as Parkinson’s disease, electrical stimulation of the brain already is widening treatment possibilities. In the future, electrical stimulation may help people with psychiatric illness and direct brain injuries, such as stroke. However, studying how brain networks interact with each other is complicated. Brain networks can […]