Study Confirms Better Survival for HPV-Positive Cervical Cancer
Cervical cancer associated with detectable human papillomavirus (HPV+) RNA or DNA had significantly better outcomes, including survival, a large meta-analysis of published studies showed. Patients who tested positive for HPV had a 62% improvement in disease-free survival (DFS), 44% improvement in cancer-specific survival (CSS), and 41% improvement in overall survival (OS), as compared with patients […]
Teen HPV Vaccine Rates Stall for First Time in a Decade
After rising steadily since 2013, new human papillomavirus (HPV) vaccinations in teens stalled for the first time in 10 years, a CDC report showed. The proportion of 13- to 17-year-olds who received at least one dose of HPV vaccine in 2022 was essentially identical to 2021 (76.0% vs 76.9%, respectively), including when it came to […]
Discordant Biomarkers Foretell Prognosis in Oropharyngeal Cancer
Mismatch between the p16 protein and human papillomavirus (HPV) biomarkers can help determine prognosis in patients with oropharyngeal cancer, European researchers reported. Specifically, oropharyngeal cancer patients with discordance between the p16 (p16INK4a ) and HPV biomarker had significantly worse disease-free survival (DFS) and overall survival (OS) than double-positive patients, though significantly better survival than double-negative […]
Could Earlier Initiation of HPV Vaccine Boost Immunization in Adolescents?
Teenagers had better vaccine coverage against human papillomavirus (HPV) if they were vaccinated at earlier ages as older children instead of early adolescents, a retrospective study showed. Early initiators vaccinated at age 9 or 10 were, compared with those who initiated at ages 11 to 12, more likely to complete the HPV vaccine series by […]
HPV Vaccination Close to Surgery May Reduce Recurrent Cervical Lesions
Vaccination for human papillomavirus (HPV) near the time of surgery for precancerous cervical lesions significantly reduced the rate of lesion recurrence, a meta-analysis showed. Overall, vaccination reduced the risk of recurrent cervical intraepithelial neoplasia grade 2+ (CIN2+) by 57% as compared with surgery alone. An even larger risk reduction (74%) occurred when the analysis was […]
HPV Immunization Program Slashed New Cervical Cancer Cases
The introduction of a human papillomavirus (HPV) immunization program in England substantially reduced cases of cervical cancer and incidence of grade 3 cervical intraepithelial neoplasia (CIN3) in young women, particularly those who received the vaccine at the age of 12 or 13, researchers found. In their register-based population study, estimated relative reductions in cervical cancer […]