Conservative Oxygenation Outperforms Liberal Targets for Critically Ill Kids
Conservative oxygenation targets in the pediatric intensive care unit (PICU) improved outcomes and reduced costs for ventilated patients, a randomized clinical trial found. The rank-based endpoint of duration of organ support or death before day 30 was significantly lower among children randomized to conservative oxygenation as opposed to liberal targets (probabilistic index 0.53, 95% CI […]
Helmet CPAP Leads Noninvasive Ventilation Therapies for Acute Respiratory Failure
The available noninvasive oxygenation strategies varied in their effectiveness in treating acute hypoxemic respiratory failure (AHRF), according to a meta-analysis of randomized trials. Helmet continuous positive airway pressure (CPAP) was the only modality that had at least moderate certainty evidence backing a probable mortality reduction compared with standard oxygen therapy (SOT; 231 fewer deaths per […]