Zanubrutinib Tops Ibrutinib in Relapsed or Refractory CLL
Treatment with the second-generation Bruton tyrosine kinase (BTK) inhibitor led to better oncologic outcomes compared with ibrutinib (Imbruvica) for patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL), according to an interim analysis of the phase III ALPINE study. Over a median follow-up of 15 months, the overall response rate — the primary […]
How Did the COVID Pandemic Affect Liver Transplant Outcomes?
The COVID-19 pandemic had a substantial impact on liver transplantation outcomes, with lower graft survival and patient survival at 90 days post-transplant versus a pre-pandemic time period, a researcher said. Graft survival was significantly lower during the COVID versus pre-COVID period (95.2% vs 96.0%) and there was a significant decline in patient survival (96.0% vs […]
Sleep Apnea Tied to Risk for Severe COVID-19
Sleep-related hypoxia was associated with worse outcomes in COVID-19 patients, a retrospective study found. In the case-control study involving patients in the Cleveland Clinic Health System, sleep-related hypoxia was linked with greater COVID-19-related hospitalization and mortality (adjusted HR 1.31, 95% CI 1.08-1.57, P=0.005), reported Reena Mehra, MD, MS, of the Cleveland Clinic Lerner Research Institute […]
TAVR Chugging Along at 5 Years in SURTAVI Trial
Researchers keeping an eye on the long-term outcomes of people undergoing transcatheter aortic valve replacement (TAVR) reported encouraging results in both clinical and economic terms, according to two reports from the Transcatheter Cardiovascular Therapeutics (TCT) meeting. The 5-year incidence of all-cause mortality or disabling stroke among people in the SURTAVI trial was no different between […]
What’s the Best Way to Treat Femur Breaks From Bone Metastases?
BALTIMORE — The use of long-stem hemiarthroplasty (LSHA) did not improve quality-of-life (QoL) or functional outcomes compared to intramedullary nailing (IMN) in treating pathological fractures of the pertrochanteric femur caused by bone metastases, a researcher reported. In the randomized controlled surgical trial, short-term outcomes (3 to 12 months) demonstrated that mean Toronto Extremity Salvage Scores […]
COVID Risk in T1D; Lilly to Drop Some Insulin Prices; New ADA/EASD T1D Guideline
Adults over age 40 with type 1 diabetes (T1D) faced more severe COVID-19 outcomes, including a higher risk of hospitalization and death, compared with children and young adults with the condition. “These findings indicate the need for age-tailored treatments, immunization, and clinical management of individuals affected by type 1 diabetes and COVID-19,” said the study’s […]
Novel small molecule potently attenuates neuroinflammation in brain and glial cells
Neuroinflammation can worsen outcomes in stroke, traumatic brain injury or spinal cord injury, as well as accelerate neurodegenerative diseases like ALS, Parkinson’s or Alzheimer’s. This suggests that limiting neuroinflammation may represent a promising new approach to treat neurological diseases and neuropathic pain that are driven by neuroinflammation. In a preclinical study published in the journal […]
Common IBD Meds Acquitted in Severe COVID Outcomes
Both biologics and mesalamine/sulfasalazine were not linked to severe COVID-19 outcomes in inflammatory bowel disease (IBD) patients, according to findings from the ongoing global SECURE-IBD trial. There was no association between mesalamine/sulfasalazine and adverse COVID outcomes. And when examining biologic-treated patients, there was no link between mesalamine/sulfasalazine use and either severe COVID-19 (adjusted odds ratio […]
Metabolic changes in plasma and immune cells associated with COVID-19 severity, can predict patient survival
COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death. After examining the blood samples from nearly 200 COVID-19 patients, researchers have uncovered underlying metabolic changes that regulate how immune cells react to the disease. These changes are associated with disease severity and could be used to […]
Indigenous and local communities key to successful nature conservation
Indigenous Peoples and local communities provide the best long-term outcomes for conservation, according to new research from the University of East Anglia (UEA) and partners in France. Lead author, Dr Neil Dawson of UEA’s School of International Development, was part of an international team conducting a systematic review that found conservation success is “the exception […]