ART Embryo Transfers to Gestational Carriers Increased Chances of Pregnancy
NEW ORLEANS — Assisted reproductive technology (ART) cycles with an embryo transfer to a gestational carrier increased the likelihood of pregnancy and live birth, an analysis of national data from 2014 to 2020 showed. In over 1 million ART cycles with an embryo transfer, those with a gestational carrier were more likely to result in […]
Dual-Chamber Leadless Pacemaker Impresses in Safety-and-Performance Study
NEW ORLEANS — A leadless dual-chamber pacemaker with bidirectional wireless communication turned in very promising short-term results in patients with standard indications for dual-chamber pacing, according to the Aveir DR i2i Study. The implantation procedure, consisting of two functioning leadless pacemakers that established implant-to-implant communication, was successful in 98.3% (n=295 of 300) of trial patients, […]
Another Win for a JAK Inhibitor in Alopecia Areata
NEW ORLEANS — Patients with severe alopecia areata had dramatic hair regrowth at 6 months with an investigational Janus kinase (JAK) inhibitor, according to a study reported here. Almost 40% of patients had at least 80% scalp coverage with the higher of two doses of the JAK 1/2 inhibitor deuruxolitinib (CTP-543), including 35% who had […]
Sotatercept, Fixed-Dose Combo Therapy on the Right Path for PAH
NEW ORLEANS — The limited clinical evidence thus far supports investigational compounds for addition to or simplification of existing frontline therapies for pulmonary arterial hypertension (PAH), according to two trials presented here at the American College of Cardiology (ACC) annual meeting. The activin signaling inhibitor biologic sotatercept showed promise as an add-on to usual treatment […]
Immediate Complete Revascularization Non-Inferior to Staged Procedure
NEW ORLEANS – Immediate complete revascularization was non-inferior to staged complete revascularization in patients who presented with acute coronary syndrome (ACS) and multivessel disease, according to BIOVASC trial findings. In the prospective, open-label study, the composite primary outcome occurred in 7.6% of 764 patients in the immediate complete revascularization group and in 9.4% of 761 […]
TEER Improves Quality of Life With Severe Tricuspid Regurgitation
NEW ORLEANS — Transcatheter edge-to-edge repair (TEER) of severely regurgitant tricuspid valves improved outcomes, largely in terms of quality of life, the TRILUMINATE Pivotal trial showed. Compared with medical therapy alone, the percutaneous placement of an investigational TriClip device to hold the leaflets together was favored in a Bayesian analysis with a win ratio of […]
Bempedoic Acid Proves Clinical Benefits for the Statin-Intolerant
NEW ORLEANS — Bempedoic acid (Nexletol) provided compelling clinical benefit in terms of primary and secondary cardiovascular prevention for statin-intolerant patients who need cholesterol lowering, according to the CLEAR Outcomes trial. Cementing its place in the arsenal of nonstatin therapies, the ATP citrate lyase inhibitor met the primary endpoint in reducing major adverse cardiovascular events […]
AML Study Suggests Intensive Chemo Unnecessary Before Allo-HCT
NEW ORLEANS — Patients with relapsed or refractory acute myeloid leukemia (AML) achieved similar outcomes with allogeneic hematopoietic stem-cell transplant (allo-HCT) whether they went to transplant as soon as possible or underwent intensive salvage chemotherapy first, the randomized ASAP trial suggested. At day 56 post-transplant, complete remission (CR) rates were a similar 84.1% for patients […]
Rigid In-Hospital Diet Offers No Advantage in Patients After HSCT
NEW ORLEANS — Patients who have neutropenia after undergoing hematopoietic stem cell transplantation (HSCT) do not need to restrict themselves to unpalatable hospital foods, a researcher said here. A randomized study of over 200 patients with hematologic diseases showed that patients who received a non-restrictive diet — including fresh fruits and vegetables, cold cuts, and […]
Oxygen Concentration During Surgery: No Help for Post-Op Nausea, Vomiting
NEW ORLEANS — There was no benefit to giving patients supplemental oxygen during surgery to reduce postoperative nausea and vomiting (PONV), according to a post hoc analysis of a randomized trial. The multiple cross-over cluster trial had eight isolated operating rooms randomized to alternate between 80% versus 30% fractions of inspired oxygen every 2 weeks […]