Vitamin C Flops for Severe COVID-19
Intravenous vitamin C did little to increase days free of organ support in adult patients hospitalized with COVID-19, two harmonized clinical trials known as LOVIT-COVID and REMAP-CAP found. Among critically ill patients given vitamin C, the median number of organ-support free days was 7 versus 10 in the control group, with an adjusted OR of […]
Older Surgical Procedure for Pelvic Prolapse Repair Prevails in Randomized Trial
A long-time surgical standard for pelvic organ prolapse repair prevailed in a comparison against a newer technique that currently predominates in some parts of the world. Sacrospinous hysteropexy failed to meet noninferiority criteria versus the Manchester procedure for the primary composite outcome of treatment success, with the latter achieving success in 87.3% of patients compared […]
‘Practice Changing’ Trial on Activity Recs After Prolapse Surgery
Telling patients who undergo pelvic organ prolapse (POP) surgery they can resume physical activity and work as soon as they’re able to resulted in noninferior anatomic and symptomatic outcomes compared with standard recommendations, a randomized trial showed. Of 107 women who underwent minimally invasive surgery at a single center, maximum anatomic POP support loss and […]
Bacteria in donor organs complicate immune response after transplantation
Organ transplant recipients take life-long immunosuppressive drugs to prevent their bodies from mounting an immune response against the donated organ, yet a substantial number of them still reject the organs. A new study by researchers from the University of Chicago shows that transplant recipients also mount an immune response against commensal bacteria in the organ […]
How High Is Breakthrough Infection Risk for People With Arthritis, HIV?
Among immunocompromised individuals vaccinated against COVID-19, solid organ transplant recipients as well as those with HIV and rheumatoid arthritis (RA) were significantly more likely to experience breakthrough infections versus people without immune dysfunction, a retrospective study found. In a national database analysis involving over 650,000 people who received at least one vaccine dose, the highest […]
West Nile Virus Infection Symptoms, Treatment, Definition & Transmission
Iwamoto, M., et al. “Transmission of West Nile Virus From an Organ Donor to Four Transplant Recipients.” N Engl J Med 348 (2003): 2196-2203. . Johnston, B. Lynn, and John M. Conly. “West Nile Virus – Where Did It Come From and Where Might It Go?” Can J Infect Dis. 11.4 July-Aug. 2000: 175-178. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094770/>. […]
FDA Panel Nearly Unanimous on Liver Transplant Perfusion Device
TransMedics’ Organ Care System liver perfusion device got near unanimous support for an indication in liver transplantation by an FDA advisory committee. The agency’s Gastroenterology and Urology Devices Panel voted 14-0 in favor of both efficacy and safety, supporting an indication for the resuscitation, preservation, and assessment of liver allografts from donors after brain death […]