Clinical Challenges: Using Pola-R-CHP for Diffuse Large B-Cell Lymphoma
Earlier this year, the FDA approved a new frontline option for patients with diffuse large B-cell lymphoma (DLBCL): the antibody-drug conjugate polatuzumab vedotin (Polivy) in combination with rituximab, cyclophosphamide, doxorubicin, and prednisone (pola-R-CHP). Combination chemotherapy involving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) — and before that, CHOP alone — has been the established option […]
FDA OKs New Frontline Endometrial Cancer Regimen, First in Decades
The FDA approved the immune checkpoint inhibitor dostarlimab (Jemperli) plus chemotherapy as a frontline option for certain patients with advanced or recurrent endometrial cancer, the agency announced on Monday. For adults with primary advanced or recurrent endometrial cancer that is mismatch repair-deficient (dMMR) or microsatellite instability-high (MSI-H), dostarlimab is now approved as part of a […]
Novel Siderophore Cephalosporin Nets Promising Results in Tough-to-Treat CRAB
WASHINGTON – Cefiderocol (Fetroja) may be a viable targeted-therapy option in critically ill patients with carbapenem-resistant Acinetobacter baumannii infections (CRAB), according to the ongoing PROVE trial. In the real-world setting, patients with CRAB often had multiple comorbidities, including severe burns, which complicates therapy, explained Stephen Marcella, MD, of Shionogi in Florham Park, New Jersey. He […]
Completing the micronutrient picture for plant-based milk alternatives
Plant-based milk alternatives are an attractive option for people with allergies or intolerances, or who prefer a dairy-free diet. However, because some essential minerals are required to be included on the Nutrition Facts label only under certain circumstances, consumers might not know if they are meeting their dietary needs. Now, researchers have analyzed plant-based beverages […]
People choose healthier food when with outsiders for fear of being negatively judged
People are more likely to choose a healthy food option than an unhealthy food option among people from different social groups because they fear being judged negatively for their choices. New research, co-authored by Bayes Business School, found that that the presence of individuals from different friendship or social groups played a role in influencing […]
Young Women Prefer Vaginal Ring as HIV Prevention
When given the option, adolescent girls and young women in Africa overwhelmingly opted to use either a drug-eluting vaginal ring or oral pre-exposure prophylaxis (PrEP) to protect against HIV infection, a researcher reported. In the so-called REACH trial, 67% of adolescent girls and young women preferred to use the dapivirine vaginal ring, 31% were happy […]