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Methotrexate Tied to Greater Risks for Older Patients With CKD

Older patients with chronic kidney disease (CKD) had greater risks for serious adverse events when starting on low-dose methotrexate rather than hydroxychloroquine, a propensity score-matched analysis found. About 60% of the cohort’s new prescription came from a rheumatologist. Within 90 days of starting either treatment, the risk for the composite outcome — a hospital visit […]

What Garcelle Beauvais Wants You To Know About Thriving After 50

Even if you maintain a healthy lifestyle at 50 and older, you’re not “too young” or “too healthy” to learn about your risk for shingles and about vaccination. We had a chance to talk with GSK’s THRIVE@50+ spokesperson Garcelle Beauvais about the realities of aging and how one impactful conversation with her pharmacist changed her […]

U.S. to Cover PrEP for Older Americans to Stem the Spread of HIV

A proposed federal policy aims to protect older Americans from contracting HIV by offering free preventive medication, the latest effort to catch up to much of Europe and Africa in stemming the spread of the virus. Under the plan from the Biden administration, Medicare would cover patients’ full cost of pre-exposure prophylaxis (PrEP) drugs, which […]

Consequences of Oral Anticoagulant Choice Magnified in the Frail

Older adults with atrial fibrillation (Afib, or AF), especially those with frailty, had better patient-centered outcomes taking apixaban (Eliquis) than other common oral anticoagulants (OACs), Medicare records showed. Compared with apixaban, rivaroxaban (Xarelto) was associated with significantly increased risk of spending more than 14 days in the hospital or a skilled nursing facility during follow-up […]

Brain Health Took a Hit During the COVID Pandemic

Brain health deteriorated more rapidly for people 50 and older during the COVID-19 pandemic, data from the PROTECT study in England suggested. Across the entire cohort of 3,100 people, both executive function (effect size 0.15) and working memory (effect size 0.51) worsened during the first year of the pandemic, according to Anne Corbett, PhD, of […]

ADHD and Car Crashes; New Guidance on Stimulant Use Disorder Tx; KarXT Heads to FDA

Older adults with attention deficit-hyperactivity disorder (ADHD) had a significantly higher incidence of car crashes. (JAMA Network Open) Meanwhile, the estimated prevalence of ADHD in kids 4 years and up held steady — between 10.08% to 10.47% — from 2017 to 2022, according to nationally representative data. (JAMA Network Open) The FDA released new draft […]

Dementia Risk Tied to Sedentary Lifestyle

People 60 and older who spent more time being sedentary — passively watching TV, for example — had a higher risk of incident all-cause dementia, prospective data suggested. The study followed about 50,000 U.K. Biobank participants living in England, Scotland, or Wales for nearly 7 years. Participants wore a wrist accelerometer for a week to […]

Complete PCI Better for Older MI Patients Too

AMSTERDAM — Complete revascularization improved outcomes over culprit-lesion-only stenting in older acute myocardial infarction (MI) patients, the FIRE trial affirmed. Among a population ages 75 and older, the composite risk of death, MI, stroke, or any revascularization came out a relative 27% less common when addressing all the stenosed vessels during the same hospitalization (15.7% […]

Breast Cancer Overdiagnosis Risk May Be Substantial for Older Women

Older women screened for breast cancer were at a considerable risk of being overdiagnosed, according to a large retrospective cohort study. Researchers found that an estimated 31% of breast cancers among screened women from the ages of 70 and 74 were potentially overdiagnosed, reported Ilana Richman, MD, MHS, of the Yale School of Medicine in […]

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