Tyrosine Kinase Inhibitor Active in Heavily Treated Renal Cell Carcinoma
NASHVILLE, Tenn. — An investigational multitargeted drug produced objective responses in clear-cell renal cell carcinoma (ccRCC), irrespective of prior exposure to cabozantinib (Cabometyx), a small clinical trial showed. Overall, 12 of 32 patients responded to zanzalintinib, including four of 17 evaluable patients with prior exposure to cabozantinib and eight of 14 without. All but one […]
HER3-Targeted Drug Active in Advanced/Metastatic Breast Cancer
An antibody-drug conjugate (ADC) targeting HER3 produced objective responses in as many as 43% of patients with advanced breast cancer, a prospective clinical trial showed. Responses to patritumab deruxtecan (HER3-DXd) occurred in the three major types of breast cancer, ranging from 22.6% in triple-negative breast cancer (TNBC) to 30.1% in hormone receptor (HR)-positive/HER2-negative breast cancer […]
Test Predicts Transition From Normal to Impaired Cognition
The Stages of Objective Memory Impairment (SOMI) system predicted transitions from normal cognition to incident symptomatic cognitive impairment, longitudinal data showed. Over a mean follow-up of about 6 years, cognitively normal older adults with memory tests scores reflecting moderate retrieval impairment (SOMI-2) were twice as likely to progress to incident cognitive impairment as those whose […]
Malnutrition links kidney disease, weaker muscles
Scientists at Osaka Metropolitan University utilized a Japan-developed, objective, and simple nutritional indicator called the Nutrition Risk Index (NRI) to unveil a long-suspected yet unverified relationship between sarcopenia and malnutrition in end-stage kidney disease patients. Their findings confirmed that malnutrition contributes to sarcopenia, which can be detected through NRI. End-stage kidney disease patients undergoing maintenance […]