High-Dose Leptin Reversed Severe Genetic Obesity in Two Patients
Personalized recombinant leptin treatment helped reverse severe, early-onset obesity in two children carrying rare antagonistic leptin genetic variants, a study showed. In the double case report, two unrelated children — a 14-year-old boy and a 2-year-old girl — presented with what appeared to be leptin dysfunction, marked by intense hyperphagia, lack of satiety, and severe […]
Researchers design an innovative strategy to fight obesity through gene therapy
A scientific team from the University of Barcelona and the CIBERobn has designed a strategy to fight obesity and diabetes in mice through ex vivo gene therapy which consists of implanting cells that have been manipulated and transformed in order to treat a disease. This is the first study to apply the ex vivo gene […]
Obesity-Related Medication Use Remains Low After Bariatric Surgery
Fewer patients with obesity used lipid-lowering, cardiovascular, or antidiabetic drugs after bariatric surgery compared with matched patients who did not have surgery for morbid obesity, a population-based cohort study in Sweden and Finland found. Bariatric surgery patients had a lower probability of receiving a prescription for one of the three categories of medication in all […]
Quarter of Wegovy-Treated Teens With Obesity Return to Normal Weight
Far more teens with obesity treated with 2.4 mg semaglutide (Wegovy) returned to normal weight or dropped below the obesity threshold compared with placebo-treated patient, a secondary analysis of the phase IIIa STEP TEENS trial found. During the 68-week trial, 44.9% of teens with obesity returned to either normal weight or went down to the […]
Bariatric Surgery May Eliminate Obesity-Related Breast Cancer Risk
Bariatric surgery for women with obesity was associated with a reduction in breast cancer risk that reached levels seen among those with a normal body mass index (BMI), researchers have found. In their retrospective study of almost 70,000 women, an increased risk for incident breast cancer was observed in women who did not undergo bariatric […]
People with obesity due to genetic predisposition have lower risk of cardiovascular disease
The risk of developing cardiovascular disease is lower in people with obesity who have a genetic predisposition for high BMI than people with obesity influenced mainly by environmental factors such as lifestyle, researchers from Karolinska Institutet report in eClinicalMedicine. There has been a global increase in the incidence of overweight and obesity over the past […]
Heart Failure’s Obesity Paradox Falls Apart on Further Inspection
For the heart failure population, BMI obesity no longer appeared to hold counterintuitive protective effects after comprehensive adjustment for natriuretic peptides and other prognostic variables in a post hoc analysis of PARADIGM. Eliminating this so-called “obesity paradox,” researchers found that study participants with the highest BMIs actually had excess combined heart failure hospitalizations and cardiovascular […]
Obesity risk may pass from mothers to daughters
Women with obesity may share risk for the disease with their daughters, but not their sons, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism. Obesity is a common, serious and costly disease affecting nearly half of the adults and 20 percent of children in the United States. […]
Microprotein increases appetite in mice: Scientists discovered more than 3,800 small proteins involved in metabolism and found that one microprotein, Gm8773, increases feeding activity in mice–providing a potential new approach to encourage weight gain in people with cancer and other diseases
Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. Tiny proteins called microproteins have long been overlooked in research, but new evidence demonstrates that they have an important role in metabolism. Salk scientists have discovered that both brown and white fat is filled with thousands of previously unknown microproteins, and […]
Weight Loss Advice From GPs Falls Flat for Patients With Obesity
Weight loss advice given by general practitioners (GPs) to patients with obesity appeared to be lacking, one U.K.-based qualitative study suggested. In an analysis of 159 audio recordings of patient consultations from the Brief Interventions for Weight Loss trial, the most common advice was diet and exercise, typically following an “eat less and do more” […]