T-Cell Receptor Gene Therapy Shows Promise in Pancreatic Cancer
A novel T-cell receptor (TCR) gene therapy may be effective in treating patients with pancreatic cancer and other cancers that express the KRAS G12D mutation, researchers have found. Their case study — published in the New England Journal of Medicine (NEJM) — showed that a heavily pretreated patient with pancreatic ductal adenocarcinoma achieved a deep […]
New measure of sperm age may be predictor of pregnancy success
A novel technique to measure the age of male sperm has the potential to predict the success and time it takes to become pregnant, according to a newly published study by researchers at the Wayne State University School of Medicine. “Sperm epigenetic clock associates with pregnancy outcomes in the general population,” (link to article here), […]
A novel therapy ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet: This therapy, using sustained release of nitric oxide, may be a novel, efficient and safe way to prevent and treat multiple metabolic diseases.
A novel therapy developed at the University of Alabama at Birmingham ameliorates obesity and Type 2 diabetes in mice fed a high-fat diet. The therapy acts through sustained release of nitric oxide, a gaseous signaling chemical whose most important function in the body is relaxing the inner muscles of blood vessels. “Because reduced bioavailability of […]
Ketone supplement might be a novel therapeutic for boosting brain function in obesity
New research published in The Journal of Physiology has shown that ketone supplements may be a novel therapeutic strategy for protecting and improving brain health in people with obesity. People with obesity are known to be at a higher risk of developing cognitive impairment and neurodegenerative diseases. This new study found that giving a ketone […]
Novel mechanism links genetic defect in IBD patients to gut leakiness: Study in mice and human tissue is the first to show how a disease mutation weakens barrier properties of epithelial cells lining the gut
A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier. The intestinal epithelium, a single layer of cells, plays […]
Novel Blood-Based Test Could Bolster MRI-Based Prostate Cancer Screening
Addition of a novel blood test to MRI-targeted biopsy in prostate cancer screening decreased overdetection while maintaining the ability to detect clinically significant cancer, Swedish researchers reported. They found that use of the test — called Stockholm3 — in a screening setting where MRI and targeted biopsies were used, performed at least as well as […]
Targeting mitochondria shows promise in treating obesity: Molecule that changes the shape of mitochondria corrects obesity
A team of University of California, Irvine, scientists have discovered a novel pharmacological approach to attenuate the mitochondrial dysfunction that drives diet-induced obesity. The results of their study were published recently in the journal, EMBO Molecular Medicine. Consuming a high-fat diet can lead to obesity and metabolic disorders such as diabetes and fatty liver. Palmitate, […]
Another Bioresorbable Stent Hits a Snag
A novel bioresorbable stent failed to meet the threshold for noninferiority compared with durable devices in the OPTIMIZE trial, and researchers suggested rising troponin use may have played a role. The Svelte stent, designed to facilitate direct stenting and transradial access in percutaneous coronary intervention (PCI), did not differ significantly from metallic everolimus-eluting stents with […]