Non-Ablative Intervention for BPH/LUTS Reduces Symptoms With Low Retreatment Rate
LAS VEGAS — A novel, non-ablative intervention for lower urinary tract symptoms (LUTS) produced rapid, durable symptom relief with no adverse effect on sexual function, long-term results from prospective study showed. Five years after treatment with the Optilume BPH catheter system, urinary flow rate (Qmax) improved by 63% and post-void residual volume (PVR) remained substantially […]
Role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation
Texas A&M AgriLife Research study may lead to novel obesity treatment New study provides insights on role of ‘hunger hormone’ receptor in obesity-realted chronic inflammation A team comprised primarily of Texas A&M AgriLife Research scientists has made an important discovery that could lead to a novel treatment for obesity and obesity-associated diseases or conditions. Details […]
Combination Shows Promise in Metastatic ESR1-Mutant Breast Cancer
A novel drug combination led to clinically meaningful antitumor activity in metastatic ESR1-mutated, estrogen receptor-positive (ER+)/HER2-negative breast cancer that had progressed on CDK4/6 inhibition, a small prospective study showed. Adding the selective estrogen receptor modulator (SERM) lasofoxifene to abemaciclib (Verzenio) resulted in a median progression-free survival (PFS) of 56 weeks, and a 24-week clinical benefit […]
Prenatal Fentanyl Exposure Suspected in Novel Syndrome
A possible link between a novel cholesterol metabolism disorder and prenatal fentanyl exposure is under investigation. The hypothesis is that prenatal fentanyl exposure possibly interferes with cholesterol metabolism, leading to findings resembling Smith-Lemli-Opitz syndrome (SLOS) in 10 infants. However, Erica Fernandes, DO, a clinical geneticist at Nemours Children’s Health in Wilmington, Delaware, and study co-authors […]
Hibernating Squirrels for Obesity? Dialysis Warning; Endocrinology and Telehealth
Could hibernating squirrels open new doors to novel obesity treatments? The new partnership between Eli Lilly and Fauna Bio plans to find out. (Endpoints News) A total of 51 members from 18 countries joined together on an expert panel to draft a consensus statement aimed at tackling diabetes stigma and discrimination. (Lancet Diabetes & Endocrinology) […]
JAK1 Inhibitor Shows ‘Remarkable’ Activity in T-Cell Lymphoma
Treatment with a novel, oral JAK1 tyrosine kinase inhibitor induced rapid and durable responses in patients with relapsed or refractory peripheral T-cell lymphoma (PTCL), findings from a single-arm phase II study showed. Among 88 heavily pretreated patients evaluable for efficacy, 44% (95% CI 34-55) responded to single-agent golidocitinib, with 24% (95% CI 15-34) achieving a […]
Dementia Risk From Midlife Onward Predicted With New Tool
A novel 14-year risk score helped identify people from age 50 onward at risk for all-cause dementia, a large U.K. study showed. The tool, called the U.K. Biobank Dementia Risk Score (UKBDRS), was developed and validated in two U.K. cohorts, reported Raihaan Patel, PhD, of the University of Oxford in England, and co-authors. The area […]
Transapical Transcatheter Mitral Valve Replacement Trial Raises Questions
PHOENIX — Global experience with the novel Intrepid transapical transcatheter mitral valve replacement (TMVR) device through 2 years showed high risks of mortality and complications, raising concerns that might not be alleviated by the planned shift to a transfemoral approach. In the analysis pooling data from a pilot study and the APOLLO trial, the high-risk […]
Is Electrical Duodenal Resurfacing the Next Big Thing for T2D and Obesity?
CHICAGO — A novel approach to revitalizing the duodenal mucosa as a means to restore normal insulin sensitivity in people with type 2 diabetes is showing strong promise in early studies, according to results presented here. In two single-arm trials of a system called ReCET, reported at Digestive Disease Week (DDW), patients with either poorly […]
Arterial stiffness may cause metabolic syndrome in adolescents via an increase in fasting insulin and LDL cholesterol
Arterial stiffness may be a novel risk factor for metabolic syndrome in teens, a paper published in the American Journal of Physiology-Heart and Circulatory Physiology concludes. The study was conducted in collaboration between the University of Bristol in the UK, the University of Exeter in the UK, and the University of Eastern Finland. The World […]