Walk It Off: Exercise Therapy for Meniscal Tears on Par With Surgery
Exercise-based physical therapy remained noninferior to arthroscopic partial meniscectomy for treating degenerative meniscal tears, according to longer-term data from the ESCAPE trial, suggesting physical therapy be the preferred treatment over surgery. By the 5-year mark, patient-reported knee function after 16 sessions of physical therapy was non-inferior to that observed after surgery, with a between-group difference […]
Methenamine Hippurate Could Be Alternative Treatment for Recurrent UTI
The urinary antiseptic methenamine hippurate (Hiprex) was non-inferior to antibiotic prophylaxis in women with a history of recurrent urinary tract infections (UTI), according to results from the ALTAR trial. Over the course of 12 months, the incidence of antibiotic-treated UTI was 0.89 and 1.38 episodes per year in patients treated with prophylactic antibiotics or methenamine […]
Study Leaves Transvaginal Mesh Controversy at Impasse
Transvaginal mesh proved noninferior to native tissue repair for vaginal prolapse but missed the superiority target in an FDA-mandated, postmarket, prospective parallel-cohort study. The 36-month composite treatment success rates were 89.3% with mesh repair and 80.2% with native tissue repair, falling within the prespecified 12% margin for noninferiority but not achieving superiority. However, mesh demonstrated […]