Heart Injuries Suggest Reconsideration of Holding BP Meds for Surgery
The practice of taking some patients briefly off their antihypertensive medications before non-cardiac surgery did not work as intended, and in fact led to excess acute hypertension in the SPACE trial. Myocardial injury rates were no worse, even numerically better, for people randomized to stay on their renin-angiotensin system (RAS) inhibitors (41.3%) compared with peers […]
Colchicine Stumbles for Protecting the Heart From Thoracic Surgery
AMSTERDAM — Anti-inflammatory colchicine (Lodoco) given perioperatively around major non-cardiac thoracic surgery did not cut atrial fibrillation (Afib) or myocardial injury complications, the COP-AF trial showed, although with some positive post hoc endpoints. Clinically important Afib occurred in 6.4% of colchicine-treated patients and 7.5% of placebo recipients (HR 0.85, 95% CI 0.65-1.10, P=0.22), David Conen, […]