FDA Panel Supports Tofersen for Rare Genetic ALS
A panel of FDA advisors voted unanimously that plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, is a reasonable surrogate endpoint in amyotrophic lateral sclerosis (ALS) associated with a mutation in the SOD1 gene (SOD1-ALS). In a 9-0 vote on Wednesday, the agency’s Peripheral and Central Nervous System Drugs Advisory Committee said the available […]
Blood Biomarker Linked With Parkinson’s Disease
Serum neurofilament light (NfL), a measure of axonal injury, was associated with incident Parkinson’s disease, parkinsonian signs, and decline in physical functioning, a longitudinal study showed. Among 1,300 people in the Chicago Health and Aging Project (CHAP), a twofold higher concentration of serum NfL was associated with incident clinical Parkinson’s disease (OR 2.54, 95% CI […]