FDA Greenlights New Myasthenia Gravis Drug
The FDA approved rozanolixizumab-noli (Rystiggo), a neonatal Fc receptor blocker, to treat adults with generalized myasthenia gravis (gMG), UCB announced Tuesday. The drug is the first approved to treat both of the two most common subtypes of gMG patients — those who are anti-acetylcholine receptor (AChR)-positive and those who are anti-muscle-specific tyrosine kinase (MuSK) antibody-positive. […]
Higher Fetal Cortisol Levels Linked to Sleep Onset Delays
INDIANAPOLIS — Higher levels of neonatal hair cortisol, a measure of fetal cortisol production in the third trimester, may have a negative effect on sleep health among infants, according to a longitudinal study. Among 70 infants in the Care Project study, greater neonatal hair cortisol levels at birth predicted longer sleep onset latency at 7 […]
Probiotic Use in NICUs Shows Some Benefits in Newborns With Very Low Birth Weight
Routine use of probiotics among newborns with very low birth weight in U.S. neonatal intensive care units (NICUs) was associated with a lower risk of necrotizing enterocolitis, but not sepsis or mortality, according to a cohort study. Among over 300,000 newborns, the incidence of necrotizing enterocolitis was reduced by 18% at NICUs that adopted use […]
Trial: Functional Scoring a Better Guide to Neonatal Opioid Withdrawal Tx
A newer function-based approach to treating neonatal opioid withdrawal syndrome safely readied babies to go home sooner, the ACT NOW randomized trial showed. With the Eat, Sleep, Console care approach, time from birth to medical readiness for hospital discharge by American Academy of Pediatrics-endorsed standards was nearly a week sooner than when treating guided by […]
In the NICU, High-Flow Oxygen Boosts Intubation Success on First Attempt
Incorporating nasal high-flow therapy during endotracheal intubation attempts in the neonatal intensive care unit (NICU) increased the chance of success on the first try, a randomized study found. In the SHINE trial of just over 250 intubation attempts at a pair of Australian NICUs, 50% of those that included high-flow therapy had a successful first […]