ICI-Related Myocarditis Deaths Down With Tailored Non-Corticosteroid Strategy
For immune checkpoint inhibitor (ICI)-associated myocarditis, increased vigilance of respiratory muscle failure and initiation of JAK‐STAT pathway inhibition led to a jump in patient survival at a Paris hospital. Based on 40 consecutive cancer patients admitted to Assistance Publique-Hôpitaux de Paris with confirmed ICI-associated myocarditis, the incidence of related death dropped from 60% during the […]
Can Biomarkers Give Early Heads-Up on Immune Checkpoint Inhibitor Myocarditis?
In the quest to catch myocarditis earlier during immune checkpoint inhibitor (ICI) therapy for cancer, researchers have found a potential role for routinely measured biomarkers. Of 2,606 consecutive ICI recipients at Michigan Medicine, the 1% who developed myocarditis often or always had elevated high-sensitivity troponin T (hsTnT; 100%), alanine aminotransferase (ALT; 88.9%), aspartate aminotransferase (AST; […]
FDA to Add Warning on Rare Myocarditis Risk After COVID Vaccination
Given the reported cases of myocarditis in young people who received mRNA COVID-19 vaccines, FDA will include a warning statement about the risks and characteristics of this rare condition, an agency representative said at CDC’s Advisory Committee on Immunization Practices (ACIP) meeting on Wednesday. Data presented by CDC staff estimated a rate of 12.6 cases […]