How Well Do Opioids Stack Up for Musculoskeletal Pain in the ED?
For musculoskeletal pain in the emergency department (ED), opioids weren’t clearly better than other analgesics across studies in a systematic review and meta-analysis. When evaluated at a median of around 2 hours of follow-up, opioids were not statistically or clinically more effective against pain than nonsteroidal anti-inflammatory drugs (NSAIDs; mean difference [MD] -0.1 on a […]
Nerves may be key to blocking abnormal bone growth in tissue: Drugs being investigated for pain relief may prevent heterotopic ossification, study suggests.
Blocking a molecule that draws sensory nerves into musculoskeletal injuries prevents heterotopic ossification (HO), a process in which bone abnormally grows in soft tissue during healing, UT Southwestern researchers reported in a study. The findings, published in Nature Communications, suggest that drugs currently being tested in clinical trials to inhibit this molecule for pain relief […]