Low-Dose Intradermal Mpox Vaccine on Par With Subcutaneous Dosing
Mpox vaccination with a two-shot, low-dose intradermal approach produced similar antibody titers levels compared with the standard subcutaneous dosing regimen, an observational study showed. Two 0.1-mL intradermal doses of the modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine yielded geometric mean titers of immunoglobulin G (IgG) antibodies that neutralize mpox of 88.65 (95% CI 48.09-163.42), compared with […]
Uncontrolled HIV a Risk Factor for Severe Mpox, Global Analysis Confirms
BRISBANE, Australia — The elevated risk of severe mpox in people living with HIV appeared restricted to those with uncontrolled HIV or immunosuppression from other conditions, according to an update on the global outbreak from World Health Organization (WHO) researchers. Of more than 32,000 cases of mpox (formerly monkeypox) reported worldwide where patients’ HIV status […]
CDC Offers Tentative Guidance for Severe Mpox Treatment
With no clinical trial data yet available for treating severe mpox, the CDC has published an interim report with guidance. There are many FDA-regulated drugs and biologics stockpiled for smallpox preparedness that can be used to treat severe mpox; however, there are many clinical considerations when using these to help manage strategic decision-making, the CDC […]
Severe Mpox in Advanced HIV Patients Tied to Complications, Death
SEATTLE — Among people living with HIV, a severe form of mpox in the context of immunosuppression appeared to lead to complications and even death, according to a global case series. In a cohort of 382 patients, severe complications most commonly occurred in those with a CD4 cell count <100 cells/mm3 compared with those with […]
WHO Renames Monkeypox As Mpox, Citing Racism Concerns
LONDON (AP) — The World Health Organization has renamed monkeypox as mpox, citing concerns the original name of the decades-old animal disease could be construed as discriminatory and racist. The U.N. health agency said in a statement Monday that mpox was its new preferred name for monkeypox, saying that both monkeypox and mpox would be […]