Metabolic diseases may be driven by gut microbiome, loss of ovarian hormones
The gut microbiome interacts with the loss of female sex hormones to exacerbate metabolic disease, including weight gain, fat in the liver and the expression of genes linked with inflammation, researchers found in a new rodent study. The findings, published in the journal Gut Microbes, may shed light on why women are at significantly greater […]
Do sugar-free candy and gum give you gas? Researchers think they know why
Researchers at UC Davis have identified changes in the gut microbiome that can result in an inability to digest sorbitol. Sorbitol, a sugar alcohol, is used in sugar-free gum, mints, candy and other products. It is also found naturally in apricots, apples, pears, avocadoes and other foods. At high levels, sorbitol can cause bloating, cramps […]
Manipulation of gut microbiota with flaxseed could reduce breast cancer risk
A new study demonstrates that the human gut microbiome may be a factor in breast health. Lifestyle and diet have long been known to affect human health. In the study, flaxseed components called lignans were shown to influence the relationship between gut microorganisms and the expression of mammary gland microRNAs (miRNAs). A subset of these […]
Microbiome Study Provides New Clues to Common Pathology of Inflammatory Conditions
An alteration in gut microbiome diversity occurred in patients with three different inflammatory conditions, suggesting a common pathology, prospective rRNA sequencing of patients’ stool samples showed. Patients with axial spondyloarthritis (SpA), acute anterior uveitis (AAU), and Crohn’s disease had a low concentration of Lachnospiraceae compared with a control group of patients with back pain and […]
Gut microbiomes of mouse pups are permanently altered when moms are fed a low-fiber diet while nursing
The first things that mouse newborns touch and eat establishes their native microbiome, which is often influenced by their mother during birth and throughout nursing. Although diet has been a known contributor to obesity in all stages of life, the effects of nursing mothers’ diets is an ongoing investigation. In a paper publishing December 8th […]
Oral Microbiome Therapy Tied to Low Recurrence of C. Diff
A potential first-in-class investigational microbiome therapeutic, SER-109, was safe and observed to sustain low Clostridioides difficile (C. diff) recurrence rates for adults, according to the phase III, single-arm ECOSPOR IV study. Recurrence of C. diff infections occurred in 8.7% of patients at week 8 after receiving a short course of capsules containing purified Firmicutes bacteria […]
Sugar disrupts microbiome, eliminates protection against obesity and diabetes
A study of mice found that dietary sugar alters the gut microbiome, setting off a chain of events that leads to metabolic disease, pre-diabetes, and weight gain. The findings, published today in Cell, suggest that diet matters, but an optimal microbiome is equally important for the prevention of metabolic syndrome, diabetes, and obesity. Diet alters […]
Antibiotics affect male and female gut microbiomes differently: Sex-specific changes in the gut bacteria of lab rats treated with antibiotics
In a new study, researchers at Cedars-Sinai found that antibiotics have sex-specific effects on the gut microbiome makeup of male and female laboratory rats. The findings, published in the journal Frontiers in Microbiology, could have implications for using the drugs in humans to treat or prevent bacterial infection. “We found that giving the rats a […]
Gut microbiome may alter response to cancer therapy
Since ancient times, our gut microbiome, home to a vast number of bacteria, viruses, fungi, and other microorganisms, has been thought to influence many aspects of human health. Most recently, sequencing technology has shown that it may also play a role in the treatment of cancer. A review paper published in JAMA Oncology by investigators […]
Link found between gut microbes and stroke: Findings lay the groundwork for new stroke treatments, prevention strategies
New findings from Cleveland Clinic researchers show for the first time that the gut microbiome impacts stroke severity and functional impairment following stroke. The results, published in Cell Host & Microbe, lay the groundwork for potential new interventions to help treat or prevent stroke. The research was led by Weifei Zhu, Ph.D., and Stanley Hazen, […]