Alzheimer’s Disease Detected in Blood a Decade Before Clinical Symptoms
Blood concentrations of glial fibrillary acidic protein (GFAP), a marker of astrogliosis, were higher about 10 years before symptom onset in an inherited form of Alzheimer’s disease. Three plasma biomarkers — phosphorylated tau (p-tau181), neurofilament light chain (NfL), and GFAP — were higher in mutation carriers than non-carriers in a Swedish cohort of autosomal dominant […]
Abnormal response to cellular stress is associated with Huntington’s disease
A new University of California, Irvine-led study finds that the persistence of a marker of chronic cellular stress, previously associated with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), also takes place in the brains of Huntington’s disease (HD) patients. Chronic cellular stress results in the abnormal accumulation of stress granules […]